Comparing Two Ways to Manage Head and Neck Lymphedema

Last updated: April 29, 2025
Sponsor: Abramson Cancer Center at Penn Medicine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lymphedema

Nasopharyngeal Cancer

Human Papilloma Virus (Hpv)

Treatment

Clinic-based CDT

Home-based (a hybrid model) CDT

Clinical Study ID

NCT05182229
UPCC 20321
  • Ages > 18
  • All Genders

Study Summary

This randomized clinical trial aims to compare clinic-based CDT and home-based (a hybrid model) CDT on changes in the severity of lymphedema, symptom burden, functional status, and healthcare utilization in HNC survivors with lymphedema.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • >18 years of age

  • <=24 months post-HNC treatment

  • Diagnosis of head and neck lymphedema and referral by their oncology providers

  • Able to perform self-manual lymphatic drainage

  • Having an electronic device (a computer, tablet, iPad, laptop, or smartphone) andinternet access at home

Exclusion

Exclusion Criteria:

  • Active infection in soft tissues in the head and neck region

  • History of moderate or severe carotid artery occlusion

  • Significantly severe lymphedema (e.g., severe periorbital swelling)

  • Conditions impacting the safe delivery of lymphedema therapy

Study Design

Total Participants: 300
Treatment Group(s): 2
Primary Treatment: Clinic-based CDT
Phase:
Study Start date:
March 11, 2022
Estimated Completion Date:
November 30, 2026

Study Description

Primary aim: To compare the effects of clinic-based and home-based (a hybrid model) CDT on changes in the severity of lymphedema.

Secondary aim: To compare the effects of clinic-based and home-based (a hybrid model) CDT on symptom burden and functional status.

Exploratory aim: To compare the healthcare utilization between patients receiving clinic-based versus home-based (a hybrid model) CDT

Connect with a study center

  • Jefferson Cherry Hospital Jefferson Health

    Cherry Hill, New Jersey 08002
    United States

    Active - Recruiting

  • Jefferson Health

    Philadelphia, Pennsylvania 19107
    United States

    Active - Recruiting

  • Jefferson Torresdale Hospital Jefferson Health

    Philadelphia, Pennsylvania 19114
    United States

    Site Not Available

  • Temple University Hospital and Fox Chase Cancer Center

    Philadelphia, Pennsylvania 19140
    United States

    Active - Recruiting

  • Thomas Jefferson University

    Philadelphia, Pennsylvania 19107
    United States

    Active - Recruiting

  • University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

  • Asplundh Cancer Pavilion Jefferson Health

    Willow Grove, Pennsylvania 19090
    United States

    Active - Recruiting

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