A Study to Evaluate the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease

Inclusion Criteria:

• Males and females must be ≥ 18 to ≤ 80 years of age at the time of signing theinformed consent form (ICF).

• Diagnosis of pulmonary hypertension (PH) associated with interstitial lung disease (ILD) (including idiopathic interstitial pneumonia [IIP], idiopathic pulmonaryfibrosis [IPF], connective tissue disease [CTD], sarcoidosis).

• Male and female participants must use contraceptives that are consistent with localregulations regarding the methods of contraception for those participating inclinical studies.

• Male participants:

Male participants who are not sterile, with female partners of childbearing potential, must be using effective contraception from Day 1 to at least 90 days after the last dose of study drug.

Male participants with women of child bearing potential (WOCBP) partner must use a condom in order to avoid potential exposure to embryo/fetus.

• Female participants: Women must be postmenopausal (defined as no menses for 12months without an alternative medical cause), surgically sterile, (ie,hysterectomyand/or bilateral salpingo-oophorectomy) or using highly effective contraceptionmethods (ie, methods that alone or in combination achieve <1% unintended pregnancyrates per year when used consistently and correctly) from Day 1 to at least 90 daysafter the last dose of study drug.

• Capable of giving signed informed consent that includes compliance with therequirements and restrictions listed in the ICF and in this protocol.

Exclusion Criteria:

• Primary diagnosis of chronic obstructive pulmonary disease (COPD).

• Allergy, or documented hypersensitivity or contraindication to TPIP or treprostinil (TRE) or mannitol (an excipient of the TPIP formulation).

• Received or currently treated with riociguat, endothelin receptor antagonists,selexipag, phosphodiesterase 5 (PDE5) inhibitors and/or prostacyclin analogueswithin 30 days prior to Screening.

• Started therapy with pirfenidone or nintedanib < 90 days prior to Screening, OR, ifalready receiving either medication, there is a dose change within 30 days ofScreening Visit.

• Any known ventricular or supraventricular tachyarrhythmia (except for paroxysmalatrial fibrillation), and/or any symptomatic bradycardia.

• History of heart disease including left ventricular ejection fraction (LVEF) ≤ 40%or clinically significant valvular, constrictive, or symptomatic atheroscleroticheart disease (eg, stable angina, myocardial infarction, etc).

• Participation in a cardiopulmonary rehabilitation program within 30 days of thefirst Screening Visit. Participation in the maintenance program of a cardiopulmonaryrehabilitation program is allowed.

• Acutely decompensated heart failure within 30 days of Screening Visit.

• Active and current symptomatic coronavirus disease 2019 (COVID-19) and/or previousdiagnosis of moderate to severe disease, or hospitalization due to COVID-19.

• Supplemental oxygen requirement > 10L/min at rest at Screening.

• Exacerbation of underlying lung disease or active pulmonary or upper respiratoryinfection within 30 days of the first dose of study drug (may be rescreened atappropriate time).

• Current or recent (past 30 days) lower respiratory tract infection (may berescreened at appropriate time).

• Any form of congenital heart disease or congenital heart defect (repaired orunrepaired) other than a patent foramen ovale.

• History of alcohol or drug abuse within 6 months prior to Screening.

• Current use of cigarettes (as defined by Center for Disease Control (CDC)) ore-cigarettes: An adult who has smoked at least 100 cigarettes in his or her lifetimeand who currently smokes either every day or some days.

• Participants who currently inhale marijuana (recreational or medical).

• Acute or chronic impairment (other than dyspnea), limiting the ability to complywith study requirements, in particular with 6-minute walk test (6MWT) (eg, anginapectoris, claudication, musculoskeletal disorder, need for walking aids).