Phase
Condition
Bronchiectasis
Emphysema
Chronic Obstructive Lung Disease
Treatment
Placebo
Tozorakimab
Clinical Study ID
Ages 40-130 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participant must be ≥ 40 years of age and capable of giving signed informed consent.
Documented diagnosis of COPD for at least one year prior to enrolment.
Post BD FEV1/FVC < 0.70 and post-BD FEV1 >20% of predicted normal value.
Documented history of ≥ 2 moderate or ≥ 1 severe COPD exacerbations within 12 monthsprior to enrolment.
Documented optimized inhaled dual or triple therapy at a stable dose for at least 3months prior to enrolment.
Smoking history of ≥ 10 pack-years.
CAT total score ≥10, with each of the phlegm (sputum) and cough items with a score ≥
Exclusion
Exclusion Criteria:
Clinically important pulmonary disease other than COPD.
Radiological findings suggestive of a respiratory disease other than COPD that issignificantly contributing to the participant's respiratory symptoms.
Current diagnosis of asthma, prior history of asthma, or asthma-COPD overlap.Childhood history of asthma is allowed and defined as asthma diagnosed and resolvedbefore the age of 18.
Any unstable disorder, including, but not limited to, cardiovascular,gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious,endocrine, metabolic, haematological, psychiatric disorder, major physical and/orcognitive impairment that could affect safety, study findings or participantsability to complete the study.
COPD exacerbation, within 2 weeks prior to randomization, that was treated withsystemic corticosteroids and/or antibiotics, and/or led to hospitalization.
Active significant infection within the 4 weeks prior to randomization, pneumoniawithin 6 weeks prior to randomization, or medical condition that predisposes theparticipant to infection.
Suspicion of, or confirmed, ongoing SARS-CoV-2 infection.
Significant COVID-19 illness within the 6 months prior to enrolment.
Unstable cardiovascular disorder.
Diagnosis of cor pulmonale, pulmonary arterial hypertension and/or right ventricularfailure.
History of known immunodeficiency disorder, including a positive test for HIV-1 orHIV 2.
History of positive test or treatment for hepatitis B or hepatitis C (except forcured hepatitis C)
Evidence of active liver disease, including jaundice during screening.
Malignancy, current or within the past 5 years, except for adequately treatednon-invasive basal cell and squamous cell carcinoma of the skin and cervicalcarcinoma-in-situ treated with apparent success more than one year prior toenrolment. Suspected malignancy or undefined neoplasms.
Participants who have evidence of active TB.
Participants that have previously received tozorakimab.
Any clinically significant abnormal findings in physical examination, vital signs,ECG, or laboratory testing during the screening period, which in the opinion of theinvestigator may put the participant at risk because of their participation in thestudy, or may influence the results of the study, or the participant's ability tocomplete the entire duration of the study.
Active vaping of any products or using smoked marijuana within the 6 months prior torandomization and during the study.
Study Design
Connect with a study center
Research Site
Buenos Aires, C1121 ABE
ArgentinaSite Not Available
Research Site
Caba, C1425BEN
ArgentinaSite Not Available
Research Site
Córdoba, X5003DCE
ArgentinaSite Not Available
Research Site
Florencio Varela, 1888
ArgentinaSite Not Available
Research Site
Mar del Plata, 7600
ArgentinaSite Not Available
Research Site
Mendoza, M5500CCG
ArgentinaSite Not Available
Research Site
Quilmes, B1878FNR
ArgentinaSite Not Available
Research Site
Ranelagh, 1886
ArgentinaSite Not Available
Research Site
San Fernando, B1646EBJ
ArgentinaSite Not Available
Research Site
San Miguel de Tucuman, 4000
ArgentinaSite Not Available
Research Site
Tucumán, 4000
ArgentinaSite Not Available
Research Site
Bruxelles, 1000
BelgiumSite Not Available
Research Site
Edegem, 2650
BelgiumSite Not Available
Research Site
Gent, 9000
BelgiumSite Not Available
Research Site
Leuven, 3000
BelgiumSite Not Available
Research Site
Liege, 4000
BelgiumSite Not Available
Research Site
Namur, 5101
BelgiumSite Not Available
Research Site
Roeselare, 8800
BelgiumSite Not Available
Research Site
Dupnitsa, 2600
BulgariaSite Not Available
Research Site
Haskovo, 6305
BulgariaSite Not Available
Research Site
Kozloduy, 3320
BulgariaSite Not Available
Research Site
Lovech, 5500
BulgariaSite Not Available
Research Site
Petrich, 2850
BulgariaSite Not Available
Research Site
Pleven, 5800
BulgariaSite Not Available
Research Site
Ruse, 7002
BulgariaSite Not Available
Research Site
Sandanski, 2800
BulgariaSite Not Available
Research Site
Sliven, 8800
BulgariaSite Not Available
Research Site
Sofia, 1000
BulgariaSite Not Available
Research Site
Troyan, 5600
BulgariaSite Not Available
Research Site
Varna, 9000
BulgariaSite Not Available
Research Site
Vratsa, 3000
BulgariaSite Not Available
Research Site
Calgary, Alberta T3E 7M8
CanadaSite Not Available
Research Site
Edmonton, Alberta T5A 4L8
CanadaSite Not Available
Research Site
Sherwood Park, Alberta T8L 0N2
CanadaSite Not Available
Research Site
Kamloops, British Columbia V2C 5T1
CanadaSite Not Available
Research Site
Kelowna, British Columbia V1Y 4N7
CanadaSite Not Available
Research Site
Moncton, New Brunswick E1G 1A7
CanadaSite Not Available
Research Site
Ajax, Ontario L1S 2J5
CanadaSite Not Available
Research Site
Barrie, Ontario L4N 1B3
CanadaSite Not Available
Research Site
Guelph, Ontario N1H 6J2
CanadaSite Not Available
Research Site
Hamilton, Ontario L8M 1K7
CanadaSite Not Available
Research Site
Markham, Ontario L3T 0C8
CanadaSite Not Available
Research Site
Stouffville, Ontario L4A 1H2
CanadaSite Not Available
Research Site
Thornhill, Ontario L3T 0C8
CanadaSite Not Available
Research Site
Winchester, Ontario K0C 2K0
CanadaSite Not Available
Research Site
Montreal, PQ H3T 1E2
CanadaSite Not Available
Research Site
Terrebonne, Quebec J6V 2H2
CanadaSite Not Available
Research Site
Quebec, G1V 4G5
CanadaSite Not Available
Research Site
Blansko, 678 31
CzechiaSite Not Available
Research Site
Brno, 625 00
CzechiaSite Not Available
Research Site
Broumov, 55001
CzechiaSite Not Available
Research Site
Jihlava, 586 33
CzechiaSite Not Available
Research Site
Jindrichuv Hradec, 377 01
CzechiaSite Not Available
Research Site
Kyjov, 697 01
CzechiaSite Not Available
Research Site
Liberec 1, 460 63
CzechiaSite Not Available
Research Site
Mlada Boleslav, 293 01
CzechiaSite Not Available
Research Site
Olomouc, 779 00
CzechiaSite Not Available
Research Site
Rokycany, 337 22
CzechiaSite Not Available
Research Site
Aarhus, 8200
DenmarkSite Not Available
Research Site
Hvidovre, 2650
DenmarkSite Not Available
Research Site
København NV, 2400
DenmarkSite Not Available
Research Site
Næstved, 4700
DenmarkSite Not Available
Research Site
Roskilde, 4000
DenmarkSite Not Available
Research Site
Vejle, 7100
DenmarkSite Not Available
Research Site
Ålborg, 9000
DenmarkSite Not Available
Research Site
Helsinki, 00290
FinlandSite Not Available
Research Site
Hämeenlinna, 13530
FinlandSite Not Available
Research Site
Kuopio, 70210
FinlandSite Not Available
Research Site
Tampere, 33520
FinlandSite Not Available
Research Site
Turku, 20520
FinlandSite Not Available
Research Site
Baja, 6500
HungarySite Not Available
Research Site
Budapest, 1036
HungarySite Not Available
Research Site
Debrecen, 4032
HungarySite Not Available
Research Site
Edelény, 3780
HungarySite Not Available
Research Site
Encs, 3860
HungarySite Not Available
Research Site
Gyöngyös, 3200
HungarySite Not Available
Research Site
Mosonmagyaróvár, 9200
HungarySite Not Available
Research Site
Nyíregyháza-Sóstóhegy, 4481
HungarySite Not Available
Research Site
Százhalombatta, 2440
HungarySite Not Available
Research Site
Székesfehérvár, 8000
HungarySite Not Available
Research Site
Ahmedabad, 382415
IndiaSite Not Available
Research Site
Aligarh, 202002
IndiaSite Not Available
Research Site
Belagavi, 590010
IndiaSite Not Available
Research Site
Coimbatore, 641028
IndiaSite Not Available
Research Site
Dehradun, 248001
IndiaSite Not Available
Research Site
Hyderabad, 500038
IndiaSite Not Available
Research Site
Jaipur, 302039
IndiaSite Not Available
Research Site
Kolkatta, 700027
IndiaSite Not Available
Research Site
Mohali, 160062
IndiaSite Not Available
Research Site
Nagpur, 440012
IndiaSite Not Available
Research Site
Nashik, 422007
IndiaSite Not Available
Research Site
New Delhi, 110029
IndiaSite Not Available
Research Site
Surat, 395009
IndiaSite Not Available
Research Site
Thane, 401107
IndiaSite Not Available
Research Site
Asahikawa-shi, 078-8510
JapanSite Not Available
Research Site
Bunkyo-ku, 113-8519
JapanSite Not Available
Research Site
Chikushino-shi, 818-8502
JapanSite Not Available
Research Site
Chuo-ku, 103-0022
JapanSite Not Available
Research Site
Fujieda-shi, 426-8677
JapanSite Not Available
Research Site
Fukuoka-shi, 819-8555
JapanSite Not Available
Research Site
Hamamatsu-shi, 431-3192
JapanSite Not Available
Research Site
Himeji-shi, 672-8064
JapanSite Not Available
Research Site
Hiroshima-shi, 734-8530
JapanSite Not Available
Research Site
Iizuka-shi, 820-8505
JapanSite Not Available
Research Site
Itabashi-ku, 173-8610
JapanSite Not Available
Research Site
Iwata-shi, 438-8550
JapanSite Not Available
Research Site
Izumi-shi, 594-0073
JapanSite Not Available
Research Site
Joyo-shi, 610-0113
JapanSite Not Available
Research Site
Kagoshima-shi, 890-8520
JapanSite Not Available
Research Site
Kakogawa-shi, 675-8611
JapanSite Not Available
Research Site
Kamogawa-shi, 296-0041
JapanSite Not Available
Research Site
Kanazawa-shi, 920-8650
JapanSite Not Available
Research Site
Kawachinagano-shi, 586-8521
JapanSite Not Available
Research Site
Kawasaki-shi, 216-8511
JapanSite Not Available
Research Site
Kitakyusyu, 802-0052
JapanSite Not Available
Research Site
Kitakyusyu-shi, 806-8501
JapanSite Not Available
Research Site
Kiyose-shi, 204-8585
JapanSite Not Available
Research Site
Kobe-shi, 651-0072
JapanSite Not Available
Research Site
Kofu-shi, 400-8506
JapanSite Not Available
Research Site
Koga-shi, 811-3195
JapanSite Not Available
Research Site
Kokubunji-shi, 185-0014
JapanSite Not Available
Research Site
Koto-ku, 136-0075
JapanSite Not Available
Research Site
Matsusaka-shi, 515-8544
JapanSite Not Available
Research Site
Meguro-ku, 153-8515
JapanSite Not Available
Research Site
Mitaka-shi, 181-8611
JapanSite Not Available
Research Site
Miyazaki-shi, 880-8510
JapanSite Not Available
Research Site
Mizunami-shi, 509-6134
JapanSite Not Available
Research Site
Nagaoka-shi, 940-8621
JapanSite Not Available
Research Site
Nagoya-shi, 460-0001
JapanSite Not Available
Research Site
Narita-shi, 286-8520
JapanSite Not Available
Research Site
Niigata-shi, 950-1197
JapanSite Not Available
Research Site
Nishinomiya-shi, 663-8501
JapanSite Not Available
Research Site
Obihiro, 080-0017
JapanSite Not Available
Research Site
Okayama, 700-8558
JapanSite Not Available
Research Site
Okayama-shi, 702-8055
JapanSite Not Available
Research Site
Osaka-shi, 543-8555
JapanSite Not Available
Research Site
Sakai-shi, 590-0064
JapanSite Not Available
Research Site
Sakaide-shi, 762-0031
JapanSite Not Available
Research Site
Saku-shi, 385-0051
JapanSite Not Available
Research Site
Sapporo-shi, 062-0931
JapanSite Not Available
Research Site
Sendai-Shi, 984-0042
JapanSite Not Available
Research Site
Seto-shi, 489-8642
JapanSite Not Available
Research Site
Shinjuku-ku, 162-8655
JapanSite Not Available
Research Site
Shizuoka-shi, 420-8630
JapanSite Not Available
Research Site
Tachikawa-shi, 190-0014
JapanSite Not Available
Research Site
Takamatsu-shi, 760-0018
JapanSite Not Available
Research Site
Toshima-ku, 170-0003
JapanSite Not Available
Research Site
Toyama-shi, 930-8550
JapanSite Not Available
Research Site
Toyonaka-shi, 560-8552
JapanSite Not Available
Research Site
Wakayama-shi, 640-8505
JapanSite Not Available
Research Site
Yamagata-shi, 990-9585
JapanSite Not Available
Research Site
Yanagawa-shi, 832-0059
JapanSite Not Available
Research Site
Yokohama-shi, 221-0855
JapanSite Not Available
Research Site
Daegu, 42415
Korea, Republic ofSite Not Available
Research Site
Incheon, 21431
Korea, Republic ofSite Not Available
Research Site
Jeonju-si, 54907
Korea, Republic ofSite Not Available
Research Site
Seoul, 05505
Korea, Republic ofSite Not Available
Research Site
Benito Juarez, 03650
MexicoSite Not Available
Research Site
Chihuahua, 31000
MexicoSite Not Available
Research Site
Durango, 34080
MexicoSite Not Available
Research Site
Ecatepec de Morelos, 55450
MexicoSite Not Available
Research Site
Guadalajara, 44200
MexicoSite Not Available
Research Site
Mexico, 06700
MexicoSite Not Available
Research Site
Mexico City, 0 3100
MexicoSite Not Available
Research Site
Monterrey, 64460
MexicoSite Not Available
Research Site
Morelia, 58000
MexicoSite Not Available
Research Site
Mérida, 97070
MexicoSite Not Available
Research Site
Oaxaca, 68020
MexicoSite Not Available
Research Site
Veracruz, 91910
MexicoSite Not Available
Research Site
Alkmaar, 1815 JD
NetherlandsSite Not Available
Research Site
Eindhoven, 5623EJ
NetherlandsSite Not Available
Research Site
Groningen, 9713 GZ
NetherlandsSite Not Available
Research Site
Harderwijk, 3844 DG
NetherlandsSite Not Available
Research Site
Heerlen, 6419 PC
NetherlandsSite Not Available
Research Site
Zutphen, 7207 AE
NetherlandsSite Not Available
Research Site
Zwolle, 8025 AB
NetherlandsSite Not Available
Research Site
Bergen, 5021
NorwaySite Not Available
Research Site
Bodø, 8092
NorwaySite Not Available
Research Site
Levanger, 7600
NorwaySite Not Available
Research Site
Lørenskog, 1478
NorwaySite Not Available
Research Site
Oslo, 0450
NorwaySite Not Available
Research Site
Tønsberg, 3103
NorwaySite Not Available
Research Site
Ålesund, 6017
NorwaySite Not Available
Research Site
Guimaraes, 4835-235
PortugalSite Not Available
Research Site
Lisboa, 1998-018
PortugalSite Not Available
Research Site
Matosinhos, 4454-509
PortugalSite Not Available
Research Site
Vila Franca de Xira, 2600-009
PortugalSite Not Available
Research Site
Vila Nova de Gaia, 4434-502
PortugalSite Not Available
Research Site
Guaynabo, 00968
Puerto RicoSite Not Available
Research Site
San Juan, 00921-3201
Puerto RicoSite Not Available
Research Site
Galdakao, 48960
SpainSite Not Available
Research Site
Madrid, 28040
SpainSite Not Available
Research Site
Malaga, 29010
SpainSite Not Available
Research Site
Merida, 06800
SpainSite Not Available
Research Site
Málaga, 29010
SpainSite Not Available
Research Site
Mérida, 06800
SpainSite Not Available
Research Site
Pozuelo de Alarcon, 28223
SpainSite Not Available
Research Site
Santander, 39008
SpainSite Not Available
Research Site
Valencia, 46010
SpainSite Not Available
Research Site
Zaragoza, 50009
SpainSite Not Available
Research Site
Göteborg, 413 45
SwedenSite Not Available
Research Site
Lund, 222 22
SwedenSite Not Available
Research Site
Malmö, 205 02
SwedenSite Not Available
Research Site
Stockholm, 11239
SwedenSite Not Available
Research Site
Örebro, 70185
SwedenSite Not Available
Research Site
Ankara, 06620
TurkeySite Not Available
Research Site
Aydin, 09100
TurkeySite Not Available
Research Site
Istanbul, 34069
TurkeySite Not Available
Research Site
Izmir, 35965
TurkeySite Not Available
Research Site
Mersin, 33343
TurkeySite Not Available
Research Site
Huntsville, Alabama 35801
United StatesSite Not Available
Research Site
Mobile, Alabama 36608
United StatesSite Not Available
Research Site
Montgomery, Alabama 36106
United StatesSite Not Available
Research Site
Phoenix, Arizona 85051
United StatesSite Not Available
Research Site
Tempe, Arizona 85283
United StatesSite Not Available
Research Site
Bakersfield, California 93301
United StatesSite Not Available
Research Site
Palm Springs, California 92262
United StatesSite Not Available
Research Site
Sacramento, California 95821
United StatesSite Not Available
Research Site
Boynton Beach, Florida 33435
United StatesSite Not Available
Research Site
Jacksonville, Florida 32209
United StatesSite Not Available
Research Site
Kissimmee, Florida 34744
United StatesSite Not Available
Research Site
Ormond Beach, Florida 32174
United StatesSite Not Available
Research Site
Plantation, Florida 33324
United StatesSite Not Available
Research Site
Tampa, Florida 33606
United StatesSite Not Available
Research Site
Brookhaven, Georgia 30329
United StatesSite Not Available
Research Site
Columbus, Georgia 31904
United StatesSite Not Available
Research Site
Meridian, Idaho 83642
United StatesSite Not Available
Research Site
Chicago, Illinois 60608
United StatesSite Not Available
Research Site
Evanston, Illinois 60201
United StatesSite Not Available
Research Site
Evergreen Park, Illinois 60805
United StatesSite Not Available
Research Site
Normal, Illinois 61761
United StatesSite Not Available
Research Site
Iowa City, Iowa 52242
United StatesSite Not Available
Research Site
Kansas City, Kansas 66104
United StatesSite Not Available
Research Site
Baton Rouge, Louisiana 70816
United StatesSite Not Available
Research Site
Covington, Louisiana 70433
United StatesSite Not Available
Research Site
New Orleans, Louisiana 70112
United StatesSite Not Available
Research Site
Zachary, Louisiana 70791
United StatesSite Not Available
Research Site
Baltimore, Maryland 21224
United StatesSite Not Available
Research Site
Rochester, Minnesota 55905
United StatesSite Not Available
Research Site
Saint Louis, Missouri 63110
United StatesSite Not Available
Research Site
Missoula, Montana 59808
United StatesSite Not Available
Research Site
Brick, New Jersey 08724
United StatesSite Not Available
Research Site
Guttenberg, New Jersey 07093
United StatesSite Not Available
Research Site
Albuquerque, New Mexico 87131
United StatesSite Not Available
Research Site
Bronx, New York 10455
United StatesSite Not Available
Research Site
Buffalo, New York 14215
United StatesSite Not Available
Research Site
East Setauket, New York 11733
United StatesSite Not Available
Research Site
Hawthorne, New York 10532
United StatesSite Not Available
Research Site
Massapequa, New York 11758
United StatesSite Not Available
Research Site
New Hyde Park, New York 11042
United StatesSite Not Available
Research Site
New York, New York 10037
United StatesSite Not Available
Research Site
North Massapequa, New York 11758
United StatesSite Not Available
Research Site
Schenectady, New York 12304
United StatesSite Not Available
Research Site
Charlotte, North Carolina 28277
United StatesSite Not Available
Research Site
Durham, North Carolina 27710
United StatesSite Not Available
Research Site
Gastonia, North Carolina 28054
United StatesSite Not Available
Research Site
Raleigh, North Carolina 27607
United StatesSite Not Available
Research Site
Fargo, North Dakota 58104
United StatesSite Not Available
Research Site
DuBois, Pennsylvania 15801
United StatesSite Not Available
Research Site
Hershey, Pennsylvania 17033
United StatesSite Not Available
Research Site
Pittsburgh, Pennsylvania 15213
United StatesSite Not Available
Research Site
Sayre, Pennsylvania 18840
United StatesSite Not Available
Research Site
Greer, South Carolina 29651
United StatesSite Not Available
Research Site
Rapid City, South Dakota 57702
United StatesSite Not Available
Research Site
Franklin, Tennessee 37067
United StatesSite Not Available
Research Site
Nashville, Tennessee 37232
United StatesSite Not Available
Research Site
Cleveland, Texas 77327
United StatesSite Not Available
Research Site
Fort Worth, Texas 76107
United StatesSite Not Available
Research Site
Houston, Texas 77022
United StatesSite Not Available
Research Site
Kingwood, Texas 77339
United StatesSite Not Available
Research Site
Sherman, Texas 75092
United StatesSite Not Available
Research Site
Salt Lake City, Utah 84108
United StatesSite Not Available
Research Site
Burlington, Vermont 05401
United StatesSite Not Available
Research Site
Colchester, Vermont 05446
United StatesSite Not Available
Research Site
Manassas, Virginia 20110
United StatesSite Not Available
Research Site
Tacoma, Washington 98405
United StatesSite Not Available
Research Site
Charleston, West Virginia 25304
United StatesSite Not Available
Research Site
Marshfield, Wisconsin 54449
United StatesSite Not Available
Research Site
Hanoi, 100000
VietnamSite Not Available
Research Site
Ho Chi Minh, 700000
VietnamSite Not Available
Research Site
Ho Chi Minh City, 123
VietnamSite Not Available
Research Site
Hochiminh, 70000
VietnamSite Not Available
Not the study for you?
Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.