Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome

Last updated: February 21, 2025
Sponsor: CHU de Reims
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sleep Disorders

Sleep Apnea Syndromes

Treatment

functional magnetic resonance imaging

Clinical Study ID

NCT05147649
PA21141*
  • Ages 18-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.

Eligibility Criteria

Inclusion

Inclusion criteria :

  1. OSAS patients

  • severe OSAS with an Apnea-Hypopnea Index (AHI) > 30/h

  • without CPAP treatment

  1. Non-OSAS patients
  • absence of OSAS (AHI < 15/h and absence of excessive daytime sleepiness with Epworth score <11)

Non-inclusion criteria :

  • < 18 years old

  • >75 years old

  • left-handed

  • BMI> 40 kg/m²

  • another sleep disorder

  • central component of sleep apnea syndrome (central apnea index> 5 / h)

  • current or past neurological pathology

  • respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia)

  • MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.)

  • taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.),

  • uncorrected sensory impairment (vision or hearing)

  • protected by law.

Exclusion criteria :

  • pregnant woman according to the positive beta-hCG test result

  • left-handed following the laterality questionnaire

  • MINI results showing:

  • a current mood episode

  • a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)

  • an eating disorder

  • a diagnosis of bipolar disorder, current or past schizophrenia

Study Design

Total Participants: 70
Treatment Group(s): 1
Primary Treatment: functional magnetic resonance imaging
Phase:
Study Start date:
March 02, 2023
Estimated Completion Date:
July 02, 2026

Connect with a study center

  • Chu Reims

    Reims, 51092
    France

    Active - Recruiting

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