Meibomian Gland Probing in the Sub-Acute Phase of Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Last updated: November 23, 2021
Sponsor: Massachusetts Eye and Ear Infirmary
Overall Status: Active - Recruiting

Phase

N/A

Condition

Urticaria

Rash

Blepharitis

Treatment

N/A

Clinical Study ID

NCT05145959
2020P000608
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The investigators' aim is to study the effects of mechanical expression of meibomian glands on eyelid disease, ocular surface health in the subacute phase of SJS/TEN.

The primary outcome is to use meibomian gland imaging to assess the health and caliber of the meibomian glands of both lower eyelids, between the treated and non-treated eyes before and after the intervention. Monitoring of outcomes will be measured by comparing the results of meibography at the initial visit and at the 6-month follow-up.

The secondary outcome assessed will be patient symptoms. The Ocular Surface Disease Index survey will be administered before each treatment and patients will be asked to differentiate their symptoms between the two eyes, both before and after the intervention.

The investigators hypothesize that mechanical expression of meibomian glands within the first 6 months of SJS/TEN onset will significantly improve ocular surface disease and symptoms in those patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with SJS/TEN presenting to the Massachusetts Eye and Ear Infirmary (MEEI)ophthalmology clinic or who were seen by the ophthalmology team acutely at theMassachusetts General Hospital (MGH).
  • Patients must be in the Sub-acute phase of ocular SJS (within 6 months)
  • Patients must have evidence of Meibomitis
  • Patients must be adults (18 years of age or older)

Exclusion

Exclusion Criteria:

  • Patients with unconfirmed diagnosis of SJS vs. Erythema multiforme (or othercondition).
  • Patients beyond the sub-acute phase of SJS
  • Patients without evidence of Meibomitis (See above criteria)
  • Patients under the age of 18

Study Design

Total Participants: 30
Study Start date:
December 01, 2021
Estimated Completion Date:
March 01, 2024

Connect with a study center

  • Massachusetts Eye and Ear Hospital

    Boston, Massachusetts 02114
    United States

    Active - Recruiting

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