A Study to Evaluate Nivolumab in Combination With Ipilimumab Versus Pemetrexed With Cisplatin or Carboplatin for Unresectable Pleural Mesothelioma in Chinese Participants

Last updated: January 22, 2026
Sponsor: Bristol-Myers Squibb
Overall Status: Completed

Phase

2

Condition

Lung Cancer

Mesothelioma

Treatment

Nivolumab

Pemetrexed

Ipilimumab

Clinical Study ID

NCT05136677
CA209-6DW
U1111-1265-3913
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to assess the efficacy and safety of the combination of nivolumab and ipilimumab in Chinese participants with malignant pleural mesothelioma.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically proven diagnosis of Malignant Pleural Mesothelioma (MPM) withdetermination of epithelioid vs non-epithelioid histology

  • Must have advanced unresectable disease that is not amenable to therapy withcurative intent (surgery with or without chemotherapy)

  • Available tumor samples for centralized testing

  • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1

  • Measurable disease

Exclusion

Exclusion Criteria:

  • Primitive peritoneal, pericardial, testis or tunica vaginalis mesothelioma

  • Brain metastasis, except if surgically resected or treated with stereotaxicradiotherapy

  • Prior therapy for MPM (including chemotherapy, radical pleuropneumonectomy andnon-palliative radiotherapy)

Other protocol-defined inclusion/exclusion criteria apply

Study Design

Total Participants: 102
Treatment Group(s): 5
Primary Treatment: Nivolumab
Phase: 2
Study Start date:
January 25, 2022
Estimated Completion Date:
November 12, 2025

Connect with a study center

  • Beijing Cancer hospital-Thoracic Cancer Department A

    Beijing, Beijing 100142
    China

    Site Not Available

  • Local Institution - 0009

    Beijing, Beijing 100142
    China

    Active - Recruiting

  • Local Institution - 0009

    Beijing 1816670, Beijing Municipality 2038349 100142
    China

    Site Not Available

  • Harbin Medical University Cancer Hospital-oncology of department

    Harbin, Heilongjiang 150081
    China

    Site Not Available

  • Local Institution - 0013

    Harbin, Heilongjiang 150081
    China

    Active - Recruiting

  • Local Institution - 0013

    Harbin 2037013, Heilongjiang 2036965 150081
    China

    Site Not Available

  • Local Institution - 0006

    Zhengzhou, Henan 450003
    China

    Active - Recruiting

  • Local Institution - 0017

    Zhengzhou, Henan 450003
    China

    Site Not Available

  • The First Affiliated Hospital of Zhengzhou Universtiy-Oncology department

    Zhengzhou, Henan 450003
    China

    Active - Recruiting

  • Local Institution - 0006

    Zhengzhou 1784658, Henan 1808520 450003
    China

    Site Not Available

  • Local Institution

    Changsha, Hunan 410008
    China

    Site Not Available

  • Local Institution - 0005

    Changsha, Hunan 410013
    China

    Active - Recruiting

  • Local Institution - 0008

    Changsha, Hunan 410008
    China

    Site Not Available

  • Local Institution - 0005

    Changsha 1815577, Hunan 1806691 410013
    China

    Site Not Available

  • Local Institution - 0023

    Wuhan, Hunan 1806691 430023
    China

    Site Not Available

  • Local Institution - 0036

    Hohhot, Inner Mongolia 010020
    China

    Site Not Available

  • Local Institution - 0015

    Yangzhou, Jiangsu 225001
    China

    Active - Recruiting

  • Northern Jiangsu People's Hospital-General Surgery Department

    Yangzhou, Jiangsu 225001
    China

    Site Not Available

  • Local Institution - 0015

    Yangzhou 1787227, Jiangsu 1806260 225001
    China

    Site Not Available

  • Local Institution - 0003

    Changchun, Jilin 130021
    China

    Active - Recruiting

  • The First Hospital of Jilin University

    Changchun, Jilin 130021
    China

    Site Not Available

  • Local Institution - 0003

    Changchun 2038180, Jilin 2036500 130021
    China

    Site Not Available

  • Local Institution

    Shen Yang, Liaoning 110044
    China

    Site Not Available

  • Liaoning Cancer Hospital-Oncology

    Shenyang, Liaoning 110042
    China

    Site Not Available

  • Local Institution

    Shenyang, Liaoning 110001
    China

    Site Not Available

  • Local Institution - 0004

    Shenyang, Liaoning 110042
    China

    Active - Recruiting

  • Local Institution - 0019

    Shenyang, Liaoning 110001
    China

    Site Not Available

  • Local Institution - 0021

    Shenyang, Liaoning 110044
    China

    Active - Recruiting

  • Local Institution - 0032

    Shenyang, Liaoning 110004
    China

    Site Not Available

  • Local Institution - 0004

    Shenyang 2034937, Liaoning 2036115 110042
    China

    Site Not Available

  • Local Institution - 0021

    Shenyang 2034937, Liaoning 2036115 110044
    China

    Site Not Available

  • Local Institution - 0037

    Jinan, Shandong 250117
    China

    Site Not Available

  • Local Institution - 0030

    Qingdao, Shandong 266003
    China

    Site Not Available

  • Local Institution - 0037

    Jinan 1805753, Shandong 1796328 250117
    China

    Site Not Available

  • Local Institution - 0030

    Qingdao 1797929, Shandong 1796328 266003
    China

    Site Not Available

  • Local Institution - 0001

    Shanghai, Shanghai 200030
    China

    Active - Recruiting

  • Local Institution - 0034

    Shanghai, Shanghai 200032
    China

    Site Not Available

  • Shanghai Chest Hospital

    Shanghai, Shanghai 200030
    China

    Site Not Available

  • Local Institution - 0001

    Shanghai 1796236, Shanghai Municipality 1796231 200030
    China

    Site Not Available

  • Local Institution - 0033

    Taiyuan, Shanxi 030000
    China

    Active - Recruiting

  • Shanxi Cancer Hospital

    Taiyuan, Shanxi 030000
    China

    Site Not Available

  • Local Institution - 0033

    Taiyuan 1793511, Shanxi 1795912 030000
    China

    Site Not Available

  • Local Institution - 0029

    Chengdu, Sichuan 610041
    China

    Active - Recruiting

  • Sichuan Cancer hospital

    Chengdu, Sichuan 610041
    China

    Site Not Available

  • Local Institution - 0029

    Chengdu 1815286, Sichuan 1794299 610041
    China

    Site Not Available

  • Local Institution - 0007

    Tianjin, Tianjin 300052
    China

    Active - Recruiting

  • Local Institution - 0018

    Tianjin, Tianjin 300060
    China

    Active - Recruiting

  • Tianjin Medical University Cancer Institute and Hospital-lung cancer

    Tianjin, Tianjin 300060
    China

    Site Not Available

  • Tianjin Medical University General Hospital-Oncology Department

    Tianjin, Tianjin 300052
    China

    Active - Recruiting

  • Local Institution - 0007

    Tianjin 1792947, Tianjin Municipality 1792943 300052
    China

    Site Not Available

  • Local Institution - 0018

    Tianjin 1792947, Tianjin Municipality 1792943 300060
    China

    Site Not Available

  • Local Institution - 0010

    Kunming, Yunnan 650106
    China

    Active - Recruiting

  • Yunnan Province Cancer Hospital

    Kunming, Yunnan 650106
    China

    Site Not Available

  • Local Institution - 0010

    Kunming 1804651, Yunnan 1785694 650106
    China

    Site Not Available

  • Local Institution

    Hangzhou, Zhejiang 310000
    China

    Site Not Available

  • Local Institution - 0014

    Hangzhou, Zhejiang 310003
    China

    Active - Recruiting

  • Local Institution - 0020

    Hangzhou, Zhejiang 310005
    China

    Active - Recruiting

  • The First Affiliated Hospital, Zhejiang University-Respiratory Department

    Hangzhou, Zhejiang 310003
    China

    Active - Recruiting

  • Zhejiang Cancer Hospital-Thoracic Surgery

    Hangzhou, Zhejiang 310005
    China

    Site Not Available

  • Local Institution - 0012

    Ningbo, Zhejiang 315010
    China

    Completed

  • Local Institution - 0016

    Ningbo, Zhejiang 315041
    China

    Active - Recruiting

  • Ningbo Medical Center-respiratory

    Ningbo, Zhejiang 315041
    China

    Site Not Available

  • Local Institution - 0014

    Hangzhou 1808926, Zhejiang 1784764 310003
    China

    Site Not Available

  • Local Institution - 0020

    Hangzhou 1808926, Zhejiang 1784764 310005
    China

    Site Not Available

  • Local Institution - 0012

    Ningbo 1799397, Zhejiang 1784764 315010
    China

    Site Not Available

  • Local Institution - 0016

    Ningbo 1799397, Zhejiang 1784764 315041
    China

    Site Not Available

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