Age Related Effects Consuming Phaeodactylum Tricornutum

Last updated: July 4, 2022
Sponsor: University of Hohenheim
Overall Status: Active - Recruiting

Phase

N/A

Condition

Aging

Treatment

N/A

Clinical Study ID

NCT05120791
MIA_E
  • Ages 65-90
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Investigation of the microalgae Phaeodactylum as food with regard to the uptake of omega-3 fatty acids and effects on various blood parameters in relation to age.

Bioavailability and excretion of nutrients and their effects on fatty acid status and inflammatory markers.

Eligibility Criteria

Inclusion

Inclusion Criteria: Age ≥60 ≤90 years, weight ≥50 kg, generally healthy

  • Signed informed consent form
  • Willingness to follow the prescribed diet for the duration of the study
  • No participation in any other clinical trial (current or within the last 30 days)

Exclusion

Exclusion Criteria:

  • Taking intestinal therapeutics, antibiotics, immunosuppressants or similar. (ifnecessary, decision on a case-by-case basis)
  • Pregnancy/breastfeeding
  • Relevant violations of the dietary protocol
  • Occurrence of relevant diseases (if necessary, individual case decision)
  • Withdrawal of consent
  • Placement in a clinic or similar facility due to official or court order

Study Design

Total Participants: 20
Study Start date:
July 01, 2022
Estimated Completion Date:
August 31, 2022

Study Description

Due to a multifaceted redesign of all areas of life, older people face many nutritional challenges, such as cognitive change, sarcopenia and micronutrient deficiency. In addition to age-associated diseases, cognitive decline is usually a precursor to neurodegenerative processes, such as Alzheimer's disease. The full molecular mechanisms are still unknown, but classic aging mechanisms, such as oxidative stress and subclinical inflammation, play a role. Due to the changed life situation, there is a reduced need for energy, while the need for nutrients remains, which greatly increases the risk of malnutrition in old age. This results in an increasing prevalence of sarcopenia. The decrease in muscle mass and strength leads to functional limitations in the elderly and also promotes oxidative stress. This increases the need for antioxidant nutrients such as carotenoids and vitamins. Studies show that age-related chronic subclinical inflammation, such as occurs in the context of an omega-6 fatty acid (-FS) emphasized diet, plays a central role in the pathogenesis of age-associated diseases

Due to this, the microalgae PT could be a goud supplier of nutrients like omega-3 FS, especially eicosapentaenoic acid (EPA), which is otherwise found mainly in fatty fish, and Fucoxanthin, an antioxidant. The investigator study the change of omega-3, -6 and -9 FS in blood plasma, in erythrocytes, as well as the change of fucoxanthin and beta-carotene. The investigator measure blood parameters for safety and control the influence on the intestinal barrier.

Connect with a study center

  • Stephan C. Bischoff, Prof. Dr

    Stuttgart, Baden-Württemberg
    Germany

    Active - Recruiting

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