Multi-model Image of Immunosuppressive Agents in TAO

Last updated: April 16, 2023
Sponsor: Sun Yat-sen University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT05110040
TAOIMTIMAGE
  • Ages 18-70
  • All Genders

Study Summary

This study aims to evaluate the efficacy of immunosuppressive agents treating Thyroid Associated Ophthalmopathy by multi-model image.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Informed consent
  • Age 18-70 years old
  • Diagnosed with TAO.

Exclusion

Exclusion Criteria:

  • Contraindications to immunosuppressive agents.
  • Patients with HIV, Hepatitis B or C, Tuberculosis or other active significantinfection.
  • Patients with severe chronic diseases in heart, lung, kidney and liver, which make itnot tolerant to immunosuppressive agents.
  • Patients have contraindications of MRI(metal pacemaker, fake teeth, foreign body andother materials which will disturb the examination).

Study Design

Total Participants: 12
Study Start date:
October 15, 2021
Estimated Completion Date:
December 01, 2025

Study Description

Thyroid Associated Ophthalmopathy is one of autoimmune orbital diseases characterized by enlargement of the extraocular muscles and increase in fatty or/and orbit connective tissue volume affecting the appearance and visual function of the eyes. TAO can be classified into active phase and inactive phase according to the activity score and wait-and-see or surgery are widely chosen for patients in inactive phase. A great number of patients in inactive phase becoming refractory and reoccurring.

Until now, the improvement of TAO is still be measured subjectively with low reliability and less accuracy. Multi-modal image is a new method to assess both the appearance and visual function of TAO and some of the indexes can be regarded as more apparent and stable in assessing the efficacy and prognosis of TAO.

This perspective cohort study aims to evaluate the efficacy of immunosuppressive agents in TAO by multi-model image and function assessments.

Connect with a study center

  • Zhongshan Ophthalmic Center

    Guangzhou, Guangdong
    China

    Active - Recruiting

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