Management of the Lack of Blood Return on a Central Venous Catheter (CVC) Before Chemotherapy

Inclusion Criteria:

• Female or male, Age ≥ 18 years at time of study entry.

• Undergoing systemic chemotherapy on a CVC. Immunotherapy and targeted therapies areamong the systemic therapies that are authorised

• Having already received at least one administration of treatment without difficulty.

• Coming for a new administration of treatment authorised by the usual biologicalassessment.

• First episode of lack of CVC blood return despite the usual positioning andinjection- aspiration manoeuvres

• No abnormality on inspection or palpation (turning) of the CVC.

• Patient has valid health insurance.

• Patient information and signature of informed consent.

Exclusion Criteria:

• Previous episode of lack of CVC blood return whether explored or not.

• Patient currently treated in an interventional therapeutic trial.

• Patient with a Picc-line implantable device.

• Suspected CVC infection or thrombosis.

• Planned chemotherapy with vesicant agent (anthracyclines).

• Possible CVC disjunction.

• Allergy to X-ray contrast agent or creatinine clearance below 30ml/min prohibitingan iodine injection.

• Pregnant, likely to be pregnant or breastfeeding woman.

• Persons deprived of their liberty, under a measure of safeguard of justice, underguardianship or placed under the authority of a guardian.

• Impossibility of undergoing medical monitoring of the trial for geographical, socialor psychological reasons, social or psychological reasons.