Asian Multicenter Prospective Study of ctDNA Sequencing

Last updated: September 2, 2024
Sponsor: National Cancer Center, Japan
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Carcinoma

Ovarian Cancer

Cervical Cancer

Treatment

NGS analysis of ctDNA

Clinical Study ID

NCT05099978
NCCH1905
  • Ages > 18
  • All Genders

Study Summary

This study is a genetic analysis of aberrations in circulating tumor DNA (ctDNA) in patients in Asian countries. This study protocol is divided into parts describing several subanalyses that differ in terms of cancer types, analytical methods, participating countries, and participating institutions.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age of 18 years or older at registration.

  2. Diagnosis of cancer which is targeted by each cohort.

  3. Metastatic and/or recurrent disease.

Exclusion

Exclusion Criteria:

  1. Any other malignancy within 3 years prior to registration, except for adequatelytreated basal cell or squamous cell skin cancer, or carcinoma in situ of theesophagus, stomach, colon, or cervix.

  2. Ongoing chemotherapy. (Chemotherapy-naïve patients or awaiting initiation of thenext line of chemotherapy are eligible. There is no limit on the number of priorchemotherapies or on the time from completion of chemotherapy to registration).

  3. Ongoing radiation therapy. (There are no limits on the time from completion ofradiation therapy to registration).

Study Design

Total Participants: 506
Treatment Group(s): 1
Primary Treatment: NGS analysis of ctDNA
Phase:
Study Start date:
November 01, 2021
Estimated Completion Date:
December 31, 2024

Study Description

NGS analysis will be performed on cfDNA extracted from peripheral blood samples of target patients to determine the types and incidences of genetic abnormalities. Patient information and gene abnormality data will be integrated, and the types and incidences of gene abnormalities by cancer type will be analyzed.

Connect with a study center

  • National Cancer Center Hospital

    Tokyo, 104-0045
    Japan

    Site Not Available

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722
    Korea, Republic of

    Site Not Available

  • Sarawak General Hospital

    Kuching, Sarawak 93586
    Malaysia

    Site Not Available

  • University Malaya Medicine Centre

    Kuala Lumpur, Selangor 59100
    Malaysia

    Site Not Available

  • Hospital Kuala Lumpur

    Kuala Lumpur, 50586
    Malaysia

    Site Not Available

  • Institut Kanser Negara

    Putrajaya, 62250
    Malaysia

    Site Not Available

  • St. Luke's Medical Center

    Manila, 1102
    Philippines

    Site Not Available

  • National Cancer Centre of Singapore

    Bukit Merah, 168582
    Singapore

    Site Not Available

  • National University Hopital

    Kent Ridge, 119228
    Singapore

    Site Not Available

  • National Taiwan University Hospital

    Taipei, Zhongzheng Dist 100225
    Taiwan

    Site Not Available

  • Chulalongkorn University

    Bangkok, 10330
    Thailand

    Site Not Available

  • Faculty of Medicine Ramathibodi Hospital, Mahidol University

    Bangkok, 10400
    Thailand

    Site Not Available

  • Mahidol University by Faculty of Medicine, Siriraj Hospital

    Bangkok, 10700
    Thailand

    Site Not Available

  • Phramongkutklao Hospital

    Bangkok, 10400
    Thailand

    Site Not Available

  • Vajira Hospital

    Bangkok, 10300
    Thailand

    Site Not Available

  • Chiang Mai University

    Chiang Mai, 50200
    Thailand

    Site Not Available

  • Songklanagarind Hospital

    Songkhla, 90110
    Thailand

    Site Not Available

  • K Hospital

    Hanoi,
    Vietnam

    Site Not Available

  • Ho Chi Minh City Oncology Hospital

    Ho Chi Minh, 708300
    Vietnam

    Site Not Available

  • Ho Chi Minh City Oncology Hospital

    Ho Chi Minh City,
    Vietnam

    Site Not Available

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