SNIFF - Combo INI+EMPA Trial

Inclusion Criteria:

1. Age 55 to 85 (inclusive)

2. Fluent in English

3. Cognitively normal or diagnosis of amnestic mild cognitive impairment (aMCI) or mildAlzheimer's disease (AD)

4. Amyloid positive by positron emission tomography (PET) or cerebrospinal fluid (CSF)criteria

5. Stable medical condition for 3 months prior to screening visit

6. Stable medications for 4 weeks prior to the screening and study visits (exceptionsmay be made on a case by case basis by the study physician)

7. Clinical laboratory values must be within normal limits or, if abnormal, must bejudged to be clinically insignificant by the study physician

Exclusion Criteria:

1. A diagnosis of dementia other than Alzheimer's disease (AD)

2. History of a clinically significant stroke

3. Current evidence or history in past two years of epilepsy, head injury with loss ofconsciousness, any major psychiatric disorder including psychosis, major depression,bipolar disorder

4. Diabetes (type I or type II) insulin-dependent and non-insulin-dependent diabetesmellitus

5. Current or past regular use of insulin or any other anti-diabetic medication within 2 months of screening visit

6. History of seizure within past five years

7. Pregnancy or possible pregnancy

8. Use of anticoagulants, unless documentation received from prescribing clinician thatanticoagulant medication can be held before LP, and approved by study clinician

9. Residence in a skilled nursing facility at screening

10. Use of an investigational agent within two months of screening visit

11. Regular use of alcohol, narcotics, anticonvulsants, anti-parkinsonian medications,or any other exclusionary medications (exceptions may be made on a case by casebasis by the study physician)