Genomic Evolution of Metastasis in Gastric Cancer

Last updated: April 27, 2022
Sponsor: University Medical Center Ho Chi Minh City (UMC)
Overall Status: Active - Recruiting

Phase

N/A

Condition

Digestive System Neoplasms

Stomach Cancer

Neoplasm Metastasis

Treatment

N/A

Clinical Study ID

NCT05061082
80/GCN-HDDD 2021
  • Ages > 18
  • All Genders

Study Summary

The aim of this study is to track tumor evolution of regional and distant metastases in gastric cancer using the Next Generation Sequencing technologies.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Male or Female patients aged 18 years and older
  2. Histologically proven primary gastric adenocarcinoma and clinical evidence ofmetastasis (N1-3M1)
  3. Biopsies can be taken at multiple sites
  4. No known other concomitant cancer diagnosis
  5. Signed informed consent

Exclusion

Exclusion Criteria:

  1. Gastric adnocarcinoma cannot be confirmed primary
  2. Unable to undergo biopsy or surgery

Study Design

Total Participants: 20
Study Start date:
October 26, 2021
Estimated Completion Date:
October 31, 2022

Study Description

Gastric cancer is the fourth most common cancer in Vietnam with high mortality rate. Metastasis is the leading cause of death in gastric cancer patients, with median overall survival of less than 1 year. Currently, there is no effective treatment because the molecular mechanism of metastasis remains unclear. The aim of this study is to use advanced NGS technologies to dissect the genomic changes (genetic, epigenetic and transcriptional changes) of the primary tumor and associated metastatic sites of the same patients. With that, the investigators can reconstruct the clonal evolution from primary tumor to metastasis, identify key pathways governing metastasis development that can be targeted for future therapeutic development.

Connect with a study center

  • University Medical Center Ho Chi Minh City

    Ho Chi Minh City, 700000
    Vietnam

    Active - Recruiting

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