Efficacy of Dalbavancin in Osteoarticular Infections Associated With Hip and Knee Replacements

Inclusion Criteria:

• Age greater than or equal to 18 years
• First monomicrobial osteoarticular infection of knee or hip prosthesis withstaphylococcus sensitive to dalbavancin (determined by a minimum inhibitoryconcentration by microdilution of the strain in question for vancomycin less than orequal to 2mg/L) and rifampicin, treated surgically by debridement, antibiotics andimplant retention with change of moving parts (acute infections) or change in 1 stage (chronic infections)
• Social security affiliation
• Signature of informed consent

Exclusion Criteria:

• Hypersensitivity to glycopeptides or rifampin or to any of the excipients
• Porphyrias
• Probabilistic antibiotic treatment not administered within 24 hours of surgery
• Probabilistic antibiotic treatment that did not take into account the bacteriumcausing the infection in its spectrum
• Acute hematogenous infection (acute secondary)
• Use of background treatment incompatible with the inducing effect of rifampicin (seeSummary of Product Characteristics for rifampicin)
• Contraindications to rifampin therapy: Moderate to severe impairment of liverfunction, patients with a history of hypersensitivity to other rifamycins, porphyria. Hepatic cirrhosis
• Use of ototoxic therapy, such as an aminoglycoside
• Renal function with glomerular filtration rate less than 30 ml/min as measured by MDRD (Modification of Diet in Renal Disease)
• Pregnant and breastfeeding women: at inclusion a blood pregnancy test will beperformed for women of childbearing age. The results will be communicated to thepatient by a physician of her choice.
• Women of childbearing age not using an effective method of contraception (pill,intrauterine device, vaginal ring, contraceptive skin patch, hormonal subcutaneousimplant, surgical sterilization)
• Protected persons defined in the following articles of the public health code: L. 1121-6: persons deprived of liberty by a judicial or administrative decision, personshospitalized without consent and persons admitted to a health or social establishment forpurposes other than research; L. 1121-8: adults subject to a legal protection measure orunable to express their consent; L. 1122-1-2: persons in emergency situations who areunable to give prior consent.