A Study to Evaluate the Efficacy and Safety of CYH33 in Patients With Recurrent/Persistent Ovary Clear Cell Carcinoma

Main Inclusion Criteria:

1. Female patients ≥ 18 years of age

2. Provide informed consent voluntarily.

3. Patients must have histologically or cytologically confirmed recurrent or persistentovarian, fallopian tube, or peritoneum clear cell carcinoma.

4. Patients with recurrent/persistent ovary, fallopian tube or primary peritoneal clearcell carcinoma, who have identified PIK3CA status.

5. Patients must have failed standard chemotherapy.

6. ECOG-PS ≤ 1.

7. Patient must have adequate organ and bone marrow function measured within 28 days ofscreening.

Main Exclusion Criteria:

Patients are ineligible for this study if they meet any of the following criteria:

1. Patient has received any anticancer therapy

2. Patients who had prior treatment with any PI3K, mTOR or AKT inhibitor.

3. Radical radiation therapy within 4 weeks prior to the first dose of theinvestigational product or received local palliative radiation therapy for bonemetastases within 2 weeks.

4. Any toxicities from prior treatment that have not recovered to baseline.

5. Patients who have been treated with any hematopoietic colony-stimulating growthfactors ≤ 2 weeks prior to starting study drug.

6. Patients who have symptomatic CNS metastasis.

7. Major surgery or had significant traumatic injury within 28 days prior to the firstdose of the investigational product or has not recovered from major side effects.

8. Known HIV infection with a history of acquired immunodeficiency syndrome (AIDS)-defining opportunity infection within the past 12 months; active hepatitis Band hepatitis C.

9. History of acute pancreatitis within 1 year of screening or past medical history ofchronic pancreatitis.

10. Patients with clinically significant cardiovascular disease