Iyengar Yoga for Prolonged Grief Disorder

Last updated: January 9, 2026
Sponsor: Medical College of Wisconsin
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Complicated Grief

Treatment

Iyengar Yoga

Socialization Control

Clinical Study ID

NCT05026827
00003864
  • Ages > 40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Experiencing the death of a loved one is inevitable for older adults. Before the coronavirus disease 2019 (COVID-19) pandemic, over 2.5 million people died annually in the United States, including 52,000 in Wisconsin alone, and COVID-19 has added to this toll. Each person who dies leaves an average of five grieving people behind. Most grieving older adults are resilient and recover their pre-loss functioning within one year. However, in about 10%, acute grief becomes protracted and debilitating, leading to the development of prolonged grief disorder (PGD), a clinically diagnosable mental health condition. PGD in older adults increases the risk for poorer medical, mental health, and cognitive outcomes; lower quality of life; disability; premature mortality; and suicide. Despite the magnitude of this problem, the neurobiology of PGD in older adults is poorly understood. By using Iyengar Yoga (IY) as a probe for PGD neurobiology, this pilot project aims to address this critical gap.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male or female greater than or equal to 40 years of age

  • Bereavement >6 months

  • Score greater than or equal to 25 on the Inventory of Complicated Grief (ICG)

  • Presence of PGD (subsyndromal and syndromal)

  • Adequate visual and auditory acuity

Exclusion

Exclusion Criteria:

  • Delirium/unstable medical conditions

  • Lifetime history of neurological illnesses: seizures, stroke, dementia of anyetiology, severe head injury, brain tumor or surgery

  • Serious back, joint or neck injuries within the past 3 months

  • Currently practicing yoga

  • Gross structural abnormalities on T1-weighted images

  • Lifetime history of the following psychiatric disorders: bipolar or psychoticdisorders, including psychotic depression

  • Current alcohol/drug abuse or dependence

  • Magnetic resonance imaging (MRI) contraindications

  • Acute suicidality

Study Design

Total Participants: 68
Treatment Group(s): 2
Primary Treatment: Iyengar Yoga
Phase:
Study Start date:
August 30, 2021
Estimated Completion Date:
December 31, 2026

Study Description

Our goal is to conduct a pilot study to examine in PGD the modulating effects of 10-week IY on circulating endocannabinoid and emotion processing brain circuit, and the associations between biological changes and clinical response.

Connect with a study center

  • Medical College of Wisconsin

    Wauwatosa, Wisconsin 53226
    United States

    Site Not Available

  • Medical College of Wisconsin

    Wauwatosa 5278159, Wisconsin 5279468 53226
    United States

    Site Not Available

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