Application of Whole-course Standardized Nutrition Management During Peri-radiotherapy in Patients With Nasopharyngeal Carcinoma After Radiotherapy: a Multicenter Randomized Controlled Clinical Study

Inclusion Criteria:

• Patients with nasopharyngeal carcinoma confirmed by histopathology
• Newly diagnosed patients without distant metastasis
• Age >18
• KPS ≥ 70
• Nasopharyngeal radiotherapy alone or concurrent chemoradiotherapy was planned to bereceived, andIMRT was used for radiotherapy
• The patient's blood counts，the lung, liver and renal functions were tolerant toradiotherapy/chemoradiotherapy（ WBC ≥ 4.0109/L, NE ≥ 2.0109/L, PLT 100109/L and Hb≥ 10g/L. AST and ALT ≤ 2.5 the upper limit（UL） ,TBIL≤1.2the UL, CRE≤1.2 the UL, andALP≤5* the UL）. And the ECG should be normal
• Good nutritional status,BMI:18~23Kg/ m2, PG-SGA ≤1,NRS 2002<3score
• No other previous neoplastic diseases, except for cured cervical carcinoma in situskin basal carcinoma
• No serious gastrointestinal diseases (moderate and severe duodenal and gastric ulcer,ulcerative colitis, Crohn's disease, etc.)
• No AIDS and no diabetes
• Clear mind, no communication barriers, able to answer questions
• Voluntarily participate and sign the informed consent in person.

Exclusion Criteria:

• Patients with gastrointestinal dysfunction, intestinal obstruction, pyloricobstruction, Acute gastrointestinal bleeding
• Patients who are allergic to nutritional therapy or have severe allergic constitution
• Uncontrolled systemic diseases, such as severe liver disease (such as cirrhosis),kidney disease, respiratory diseases and so on.
• Women who are pregnant or breastfeeding or no contraception and women with positivepregnancy test before receiving treatment
• Special dietary requirements: such as no having a certain food or a vegetarian.