Evaluation of the Relevance of Pharmacogenetics in the Prescription Off Antidepressants in a Military Population

Phase

N/A

Condition

Depression

Post-traumatic Stress Disorders

Treatment

N/A

Clinical Study ID

NCT04987047

2021RC01

2021-A00809-32

Ages 18-65
All Genders

Study Summary

The treatment of depression, anxiety disorders and post-traumatic stress disorder (PTSD) is a main public health problem due to the frequency of these pathologies and the very partial effectiveness of the existent therapies. These illnesses generally require the prescription of several successive lines of antidepressant treatments before the treatments actually become effective, leading to a several week delay during which the patient suffers from the symptoms of his/her pathology and is also likely to experience the side effects of the treatment.

Pharmacogenetics is an individualized prescribing modality that aims to predict the most favorable treatment for a given individual based on the study of genetic variants of cytochromes.

The main hypothesis of this research is that the use of pharmacogenetics in routine practice in a population of military personnel requiring a first prescription of an antidepressant is of interest to improve the tolerance and effectiveness of the treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Between 18 and 65 years-old;
To benefit from a medical follow-up in the psychiatric department of an army traininghospital;
To present a pathology requiring an antidepressant treatment and whose prescriptioncan wait 10 days;
To have given written informed consent to participate in the study.

Exclusion

Exclusion Criteria:

To be currently treated with an antidepressant or antidepressant stopped less than 15days ago;
To have one or more contraindication to the introduction of an antidepressanttreatment;
Pregnancy or breastfeeding;
To require a measure of constraint.

Study Design

November 08, 2021

November 30, 2025

Connect with a study center

Hôpital d'Instruction des Armées Percy
Clamart, 92141
France
Active - Recruiting
Hôpital d'Instruction des Armées Laveran
Marseille, 13384
France
Site Not Available
Hôpital d'Instruction des Armées Bégin
Saint-Mandé, 94160
France
Active - Recruiting
Hôpital d'Instruction des Armées Sainte-Anne
Toulon, 83000
France
Site Not Available

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