Abdominal or Transanal TME for Rectal Cancer Therapy

Last updated: August 7, 2023
Sponsor: Cantonal Hospital of St. Gallen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Digestive System Neoplasms

Colon Cancer

Colorectal Cancer

Treatment

taTME

abdTME

Clinical Study ID

NCT04969107
TMEabdVSta
  • Ages > 18
  • All Genders

Study Summary

This study assessed whether transanal TME in patients with rectal cancer is superior to open, laparoscopic, and robotic TME (abdominal TME (abTME)) regarding oncological outcome, postoperative morbidity and 90-day mortality.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • all patients receiving elective total mesorectal excision

Exclusion

Exclusion Criteria:

  • diagnosis other than rectal cancer
  • partial mesorectal excision
  • discontinuity resection (no anastomosis)
  • incomplete Staging
  • metastatic cancer
  • lack of follow-up
  • decline of a retrospective data Analysis
  • age under 18 years

Study Design

Total Participants: 300
Treatment Group(s): 2
Primary Treatment: taTME
Phase:
Study Start date:
January 01, 2012
Estimated Completion Date:
December 31, 2023

Study Description

Rectal cancer accounts for 3.8% of all new cancer diagnosis and for 3.4% of all cancer-related deaths in the world in 2020. Regarding treatment of rectal cancer, it is essential to perform surgery along the anatomical and embryological planes. This technique called total mesorectal excision (TME) reduces the local recurrence rate and improves the survival. Since the early 2000, TME has changed from open to laparoscopic approach due to better results in short-term outcome. Nevertheless, oncological benefits are modest. In 2009 the first ever transanal TME (taTME) war performed. This novel technique combines abdominal with transanal dissection. Because the distal part of the rectum is approached from below, a better visualization of the mesorectal plane resulting in higher rate of free CRM and of complete TME specimen grade (Quirke Score) can be accomplished. However, taTME remains a hot topic in the current scientific literature. In Norway and the Netherlands a higher rate of anastomotic leakage as well as a higher rate of local recurrence (9.5%) with multifocal growth pattern were described.

Connect with a study center

  • Department of surgery, Cantonal hospital of St. Gallen

    St. Gallen, Saint Gallen 9007
    Switzerland

    Active - Recruiting

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