Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization

Inclusion Criteria:

1. The patient must be ≥18 years of age
2. Presenting with silent ischemia, stable angina, or non-ST-elevation acute coronarysyndrome (NSTE-ACS)
3. Coronary artery disease with at least one native artery in which the stenosis severityis questionable (typically 30-80% stenosis)
4. FFR assessment and vFFR assessment feasible
5. The patient is willing and able to cooperate with study procedures and follow-up untilstudy completion
6. Subject is able to confirm understanding of risks, benefits and treatment alternativesand he/she provides informed consent prior to any protocol-related procedure, asapproved by the appropriate Ethics Committee

Exclusion Criteria:

1. ST-elevation myocardial infarction (STEMI) at presentation
2. Cardiogenic shock or severe hemodynamic instability at the time of intervention (heartrate<50 beats per minute, systolic blood pressure <90mmHg) or use of left ventricularassist device
3. Any target vessel with a distal Thrombolysis In Myocardial Infarction (TIMI) flow <3.
4. Presence of thrombus in intermediate target lesion.
5. Known untreated severe valvular heart disease
6. Target lesion is located in or supplied by an arterial or venous bypass graft
7. History of cardiac allograft transplantation
8. Aorto-ostial lesions with an estimated diameter stenosis >50%
9. Severe tortuosity precluding the acquisitions of 2 orthogonal projections of thetarget vessel with minimal overlap or foreshortening.
10. Absolute contraindications or allergy that cannot be pre-medicated, to iodinatedcontrast or adenosine
11. Non-cardiac co-morbidities with a life expectancy less than 1 year
12. Currently participating in another trial that is not yet at its primary endpoint. Thepatient is not allowed to participate in another investigational device or drug studyuntil the trial primary endpoint time point is achieved and may only be enrolled oncein the study
13. Women of childbearing potential who do not have a negative pregnancy test within 24hours before the procedure
14. Subject belongs to a vulnerable population (per Investigator's judgment) or subjectunable to read or write