Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema

Inclusion Criteria:

All ocular criteria apply to study eye unless otherwise noted.

1. Age ≥ 21 years.

2. Phakic or Pseudophakic with a posterior chamber intraocular lens

3. Symptomatic corneal edema associated with endothelial dysfunction which may besecondary to Fuchs corneal dystrophy or pseudophakic bullous keratopathy.

Exclusion Criteria:

All ocular criteria apply to study eye unless otherwise noted.

1. Other corneal disease

2. Anterior chamber intraocular lens, Sutured or scleral-fixated intraocular lens.

3. Macular disease that in the investigator and/or sponsor's opinion would limit theability of the subject to demonstrate improvement in BCVA.

4. History of refractive surgery.

5. Descemet membrane detachment.

6. History of uveitis or other ocular inflammatory disease.

7. History of incisional glaucoma surgery (e.g.,trabeculectomy, glaucoma drainageimplant).

8. Intraocular pressure >21 or <7 mm Hg

9. Prior incisional eye surgery within 3 months prior to study treatment or penetratingor endothelial keratoplasty.

10. History of ocular neoplasm.

11. ETDRS BCVA in the fellow eye is worse than 35 letters (Snellen equivalent of 20/200).

12. Female who is pregnant, nursing, or planning to become pregnant, or who is ofchildbearing potential and not using a reliable means of contraception during thestudy.

13. Subject is currently participating in or has participated within the last 3 monthsin any other clinical trial of an investigational drug by ocular or systemicadministration.

14. Any concomitant medical or psychological condition that could interfere with studyparticipation or is otherwise not suitable for entry into the study in the opinionof the investigator.