The Effectiveness of Stingless Bee Honey (Kelulut Honey) Versus Gel in Diabetic Wound Bed Preparation

Last updated: August 9, 2022
Sponsor: Universiti Sains Malaysia
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetic Kidney Disease

Diabetic Vitreous Hemorrhage

Diabetic Gastroparesis

Treatment

N/A

Clinical Study ID

NCT04849143
USM/JEPeM/21020186
  • Ages 18-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

There has been no study yet on the effect of stingless bee honey (Kelulut honey) produced by Melipolini sp. in diabetic wound healing in Malaysia. Kelulut honey, apart from possessing similar pro-healing properties with other honey, is also found to have a better antioxidant capacity, anti-inflammatory, and free radical scavenging activity than Tualang honey. These effects are due to the much higher content of phenolic and flavonoid substances in Kelulut honey, the key bioactive factors promoting wound healing and preventing oxidative stress-related injury. Australian researchers have also recently discovered a novel source of the rare disaccharide trehalose in stingless bee's honey, which is highly anti-diabetic and antioxidating. This study aims to investigate the efficacy of honey against gel dressing for wound bed preparation among diabetic patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male and female
  • Aged between 18-70 years old
  • Patient with full thickness cavity wound
  • Controlled diabetes mellitus (defined as: fasting blood glucose (FBG) < 10 mmol/L uponselection)

Exclusion

Exclusion Criteria:

  • Severely contaminated wound/infected
  • Patient with history of allergy to honey or stingless bee product
  • Patients who are immunocompromised or on chronic steroid use ( defined as use ofsteroid for more than 2 weeks)
  • Pregnancy
  • End stage renal failure (ESRF) patient

Study Design

Total Participants: 76
Study Start date:
September 01, 2021
Estimated Completion Date:
June 30, 2023

Connect with a study center

  • Hospital Universiti Sains Malaysia

    Kota Bharu, Kelantan 16150
    Malaysia

    Active - Recruiting

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