Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use

Inclusion Criteria:

For the patient :

• Diagnosed with major neuro-cognitive disorders (DSM V) at all severity stages.

• Leaving at home

• Assisted by a caregiver, from patient's family or personal environment, assumingmost of patient care (spending at least 6 hours per week with the patient)

• caregiver available to come with the patient to study visits as planned per protocol

• existing agitation since at least one month (according to InternationalPsychogeriatric Association (IPA) criteria)

• agitation severity ≥ 2 , based on Clinician Global Impression of Severity (CGI-S) (at least mild severity)

• the patient, his/her family member/trusted person , or his /her legal responsiblehas provided written informed consent to participate in the study

• referring physician's oral approval obtained for patient participation in the study

• Affiliated to French Healthcare System

For the caregiver:

• Has provided his/her written informed consent to participate in the study

• Ability to understand and speak French properly, ability to complete thequestionnaires and assess the patient.

• Affiliated to French Healthcare System

Exclusion Criteria:

For the patient:

• Agitation symptoms attributable either to other concomitant prescriptions, or toother psychiatric or evolving somatic diseases.

• Patient living in a residential care facility or having an institutionalizationproject within 6 months

• Patient with clinically significant or unstable disease that could affect he/herability to come for the study visit or complete the evaluations planned as perprotocol

• Concomitant participation to any other interventional research study

• Patient under legal protection.

For the caregiver:

• Caregiver under legal protection.

• Limited internet access or caregiver feeling unable to use it