Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer

Key Inclusion Criteria:

• Histologically confirmed, treatment naïve, locally advanced or metastatic (stageIIIB IV per AJCC version 8), squamous or non-squamous NSCLC with documented high PDL1 expression (TC ≥ 50%) as determined by the VENTANA SP263 IHC assay, as assessedby central laboratories).

• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1

• Must have at least 1 measurable lesion per RECIST v1.1

• Adequate organ and marrow function

• If a participant has brain or meningeal metastases, the participant must meet thefollowing criteria:

1. Have no evidence of progression by neurologic symptoms or signs for at least 4weeks prior to the first dose.

2. Participants with previously treated brain metastases may participate providedthey have stable central nervous system (CNS) disease for at least 4 weeksprior to enrollment. Stable CNS disease is defined as resolution of allneurologic symptoms to baseline, having no evidence of new or enlarging brainmetastases, and not requiring use of corticosteroids for CNS disease for atleast 14 days prior to the start of study treatment. Participants who have hadbrain metastases resected or have received whole brain radiotherapy ending atleast 4 weeks (or stereotactic radiotherapy ending at least 2 weeks) prior toinitiation of study treatment are permitted.

3. Carcinomatous meningitis is excluded regardless of clinical stability.

Key Exclusion Criteria:

• Presence of any tumor genomic aberration or driver mutation for which a targetedtherapy is approved by local health authority and available

• Use of any live vaccines against infectious diseases within 28 days of first dose

• Any active autoimmune disease or a documented history of autoimmune disease orsyndrome that required systemic treatment in the past 2 years (ie, with use ofdisease-modifying agents, corticosteroids, or immunosuppressive drugs), except forvitiligo or resolved childhood asthma/atopy.

• Prior malignancy active within the previous 2 years except for locally curablecancers that have been apparently cured, such as basal or squamous cell skin cancer,superficial bladder cancer, or carcinoma in situ of the cervix, breast, or prostatecancer

• Prior treatment with any anti-PD-1, anti-PD-L1 or any other antibody targeting animmune checkpoint.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.