Mechanical and Electrical Dyssynchrony During His-Bundle Pacing Versus His-Bundle Area Right Ventricular Pacing

Last updated: November 2, 2022
Sponsor: Medical University of Lodz
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Defect

Cardiac Disease

Heart Disease

Treatment

N/A

Clinical Study ID

NCT04697797
RNN/147/20/KE
  • Ages 18-100
  • All Genders

Study Summary

The aim of this study is to evaluate mechanical and electrical cardiac dyssynchrony in patients with pacemakers and the right ventricular electrode implanted in His Bundle area.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • all adult patients after implantation of pacemaker system with pacing leadsuccessfully captured His Bundle (selectively or/and nonselectively)

Exclusion

Exclusion Criteria:

  • not willing or incapable to give written informed consent;
  • previous implanted cardiac electronic device (pacemaker, implantablecardioverter-defibrillator, cardiac resynchronization therapy device)

Study Design

Total Participants: 100
Study Start date:
December 14, 2020
Estimated Completion Date:
December 31, 2022

Study Description

Permanent His Bundle Pacing (HBP) is a well-known method of cardiac pacing which is increasingly used in everyday practice. After lead implantation in His Bundle area (HBA) capture of various tissues can be achieved: A. right ventricular myocardium near to HBP; B. cardiac conduction system selectively or nonselectively (with concomitant regional myocardium activation). The different excitability and refractory periods decide which tissue, myocardium or/and the conduction system is effectively paced. A lot of clinical trials revealed the advantage of HBP over apical ventricular pacing (AVP). HBP improves clinical (NYHA, quality of life, hospitalization rate) and echocardiographic (left ventricular dimension and ejection fraction) indicators of heart failure.

We are going to compare mechanical and electrical synchrony during the various type of myocardium activation: HBP (nsHBP or sHBP), RV pacing near HBA and native heart rhythm (if possible) in each patient recruited to the study. Adequate pacemaker programming will allow achieving different activations as shown above. The mechanical synchrony will be estimated by transthoracic echocardiography and the electrical one by the detailed analysis of ECG.

Connect with a study center

  • Department of Electrocardiology Medical University of Lodz

    Lodz, 93-216
    Poland

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.