Bimodal and Coaxial High Resolution Ophtalmic Imaging

Last updated: November 4, 2020
Sponsor: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Overall Status: Active - Recruiting

Phase

N/A

Condition

Glaucoma

Macular Edema

Stroke

Treatment

N/A

Clinical Study ID

NCT04620876
P16-02
2016-A00704-47
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging. However, optical aberrations of the ocular media limit the resolution that can be achieved by current techniques.

The use of an adaptive optics system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many retinal microstructures: photoreceptors, vessels, bundles of nerve fibers.

Recently, the development of the coupling of the two main imaging techniques, the Adaptive Optics Ophthalmoscope with Optical Coherence Tomography, enables unparalleled three-dimensional in vivo cell-scale imaging, while remaining comfortable for the patients.

The purpose of this project is to evaluate the performance of this system for imaging micrometric retinal structures.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • People over 18

  • Patient with a pathology affecting the eye or healthy volunteer

  • Participant who signed the consent

  • Beneficiaries of the health insurance

Exclusion Criteria

  • Patients with a history of photosensitivity.

  • Patients who have just received a photodynamic therapy treatment

  • Patients taking drugs with photosensitivity as a side effect.

  • Persons with pacemakers or other implanted electronic medical device

  • Patients with viral conjunctivitis or any other infectious disease.

  • Patients with skin lesions on the neck or forehead

  • Patients at high risk of damage from optical radiation, such as aphakic patients, or patients with decreased sensitivity to light due to fundus disease.

  • Participant unable to be followed throughout the study

  • Advanced cataract or severe opacities in the anterior segment of the eye.

Study Design

Total Participants: 1200
Study Start date:
October 01, 2019
Estimated Completion Date:
October 15, 2024

Study Description

The goal of the project is the capture and analysis of images with AOSLO system, in order to evaluate the performance of this system compared to OCT imaging devices and existing Adaptive Optics used at National Hospital of Ophthalmology.

Connect with a study center

  • Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

    Paris, 75012
    France

    Active - Recruiting

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