A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Inclusion Criteria:

• Expanded Disability Status Scale (EDSS) score of 0 - 5.5 at screening.

• A diagnosis of RMS in accordance with the revised 2017 McDonald Criteria.

• Ability to complete the 9-Hole Peg Test (9-HPT) for each hand in < 240 seconds.

• Ability to perform the Timed 25-Foot Walk Test (T25FWT) in <150 seconds.

• For female participants of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and refrainfrom donating eggs.

• For male participants: agreement to remain abstinent (refrain from heterosexualintercourse) or use contraceptive measures, and refrain from donating sperm.

OLE Inclusion Criteria:

• Completed the Double-Blind Treatment (DBT) phase of the study (remaining on studytreatment; no other Disease-Modifying Therapy (DMT) administered) and who, in theopinion of the investigator, may benefit from treatment with fenebrutinib.

• Participants randomized to the teriflunomide treatment arm during the DBT phase mustundergo the accelerated teriflunomide elimination procedure (ATEP) prior to thefirst administration of open-label fenebrutinib.

• For female participants of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and refrainfrom donating eggs.

• For male participants: agreement to remain abstinent (refrain from heterosexualintercourse) or use contraceptive measures, and refrain from donating sperm.

Exclusion Criteria:

• Disease duration of > 10 years from the onset of symptoms and an EDSS score atscreening < 2.0.

• Female participants who are pregnant or breastfeeding, or intending to becomepregnant.

• Male participants who intend to father a child during the study.

• A diagnosis of primary progressive MS (PPMS) or non-active secondary progressive MS (SPMS).

• Any known or suspected active infection at screening, including but not limited to apositive screening test for Hepatitis B and C, an active or latent or inadequatelytreated infection with tuberculosis (TB), a confirmed or suspected progressivemultifocal leukoencephalopathy (PML).

• History of cancer including hematologic malignancy and solid tumors within 10 yearsof screening.

• Known presence of other neurological disorders, that could interfere with thediagnosis of MS or assessments of efficacy or safety during the study and clinicallysignificant cardiovascular, psychiatric, pulmonary, renal, hepatic, endocrine,metabolic or gastrointestinal disease.

• Rare hereditary problems of galactose intolerance, total lactase deficiency, orglucose-galactose malabsorption.

• Hypoproteinemia.

• Acute liver disease

• Chronic liver disease unless considered stable for > 6 months.

• Presence of cirrhosis (Child-Pugh Class A, B, or C) or Gilbert's Syndrome.

• Participants with significantly impaired bone marrow function or significant anemia,leukopenia, neutropenia or thrombocytopenia.

• Any concomitant disease that may require chronic treatment with systemiccorticosteroids or immunosuppressants during the course of the study.

• History of alcohol or other drug abuse within 12 months prior to screening.

• History of or currently active primary or secondary (non-drug-related)immunodeficiency, including known history of human immunodeficiency virus (HIV)infection.

• Inability to complete an MRI scan.

• Adrenocorticotropic hormone or systemic corticosteroid therapy within 4 weeks priorto screening (inhaled and topical corticosteroids are allowed).

• Receipt of a live-attenuated vaccine within 6 weeks prior to randomization.

• Any previous treatment with immunomodulatory or immunosuppressive medication withoutan appropriate washout period.

OLE Exclusion Criteria:

• Acute liver disease

• Chronic liver disease unless considered stable for > 6 months