Effect of CAFfeine on Cognition in Alzheimer's Disease

Inclusion Criteria:

• Age ≥ 50 at screening

• Probable Alzheimer dementia according to the criteria of the National Institute onAging-Alzheimer's Association; diagnosis must be supported by brain imaging (CT orMRI) and blood test (including ionogram, kidney and liver function, calcemia, CRP,TSH, B12 vitamins and folates) performed in routine care

• MMSE score ≥16

• Presence of an informant and caregiver, living with the patient

• IAChE and/or Memantine treatment non-compulsory ; If implemented it must beeffective and stable for 2 months before the selection visit and must remain stablefor the duration of the study

Exclusion Criteria:

• Patients who refuse to adopt a low caffeine diet (eviction of tea, caffeinatedsodas, chocolate in large quantities)

• Current major depressive episode according to DSM-5 criteria

• Another chronic pathology of the central nervous system

• Major anxiety according to the clinician (consistent with the corresponding nPI-Ritems that must indicate a severity >2 and an impact >3)

• Sleep disorders defined by severity and an impact on NPI-R; a patient fitted for OSAmay be included if the device has been in use for 3 months and well tolerated (stable)

• Decompensated heart disease or severe rhythm disorder (excluding slow, treated andstable chronic atrial fibrillation)

• Active smoking

• For childbearing women : pregnancy in progress or planned (A pregnancy test will beperformed)

• Patients who take forbidden treatment :

• Psychotropic treatments introduced or modified < 2 months before inclusion

• Chronic use of CYP1A2 inducing or inhibiting drugs

• All caffeine-containing specialties

• Drugs that influence caffeine metabolism

• Drugs that may interact with caffeine