PTSD, AUD, and Interpersonal Conflict: Within-person Associations

Last updated: May 8, 2023
Sponsor: University of South Dakota
Overall Status: Active - Recruiting

Phase

N/A

Condition

Alcohol Dependence

Alcohol Use Disorder

Post-traumatic Stress Disorders

Treatment

PTSD Sham

Alcohol CBM

PTSD CBM

Clinical Study ID

NCT04552782
1R01MH122954
  • Ages 18-60
  • All Genders

Study Summary

The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD symptoms, and PTSD symptoms in the real world.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • OIF/OEF/OND veterans
  • At risk for PTSD (i.e., PCL-5 ≥33) and/or AUD (i.e., AUDIT ≥ 7 (women) ≥ 8 (men))

Exclusion

Exclusion Criteria:

  • Psychosis or severe Alcohol Use Disorder that contraindicates participation (based oninterview)
  • Active suicidal or homicidal ideation that contraindicates participation (based oninterview)
  • [exclusion criteria removed 6/2022] - Severe risk for sleep apnea (a positive score inthree categories of the Berlin Questionnaire), or reported treatment for sleep apnea

Study Design

Total Participants: 250
Treatment Group(s): 4
Primary Treatment: PTSD Sham
Phase:
Study Start date:
December 04, 2020
Estimated Completion Date:
April 30, 2025

Connect with a study center

  • Bay Pines VA Health Care System

    Bay Pines, Florida 33744
    United States

    Site Not Available

  • Sioux Falls VA Health Care System

    Sioux Falls, South Dakota 57105
    United States

    Active - Recruiting

  • The University of South Dakota

    Vermillion, South Dakota 57069
    United States

    Active - Recruiting

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