A Dose-Escalation Study of SPYK04 in Patients With Locally Advanced or Metastatic Solid Tumors (With Expansion).

Inclusion Criteria:

(Both Part I and Part II)

• Age >= 18 years at time of signing informed consent form

• ECOG performance status of 0 or 1

• Patients with a locally advanced, recurrent, or metastatic solid tumor for whichstandard therapy either does not exist or has proven ineffective or intolerable

(Part I only)

• Patients with measurable and/or evaluable disease per RECIST v1.1

• Patients with MAPK pathway alterations positive solid tumor (i.e., BRAF, K/N/H-RASmutations)

(Part II only)

• Patients with measurable disease per RECIST v1.1

• Patients with KRAS mutated NSCLC (NSCLC cohort)

• Patients with KRAS mutated Ovarian Cancer (Ovarian Cancer cohort)

• Patients with RAS mutated solid tumor (Biopsy cohort)

Exclusion Criteria:

(Both Part I and Part II)

• Significant cardiovascular disease, such as New York Heart Association (NYHA)cardiac disease (Class II or greater), unstable angina, or myocardial infarctionwithin the previous 6 months or unstable arrhythmias within the previous 3 months

• Patients with primary central nervous system (CNS) malignancy, untreated CNSmetastases requiring any anti-tumor treatment, or active CNS metastases

• Patients with current severe, uncontrolled systemic disease (including, but notlimited to, clinically significant cardiovascular disease, pulmonary disease, orrenal disease, ongoing or active infection)

• Patients with a history or complication of interstitial lung disease (ILD)