Comparison of Thawing Embryos in Advance and on the Day of Transfer on Pregnancy Outcomes in FET Cycle

Last updated: July 1, 2020
Sponsor: Jinan Central Hospital
Overall Status: Active - Enrolling

Phase

N/A

Condition

In Vitro Fertilization

Treatment

N/A

Clinical Study ID

NCT04455191
JianCH-RM2020-001
  • Ages 25-35
  • Female
  • Accepts Healthy Volunteers

Study Summary

Respectively for patients with repeated transplant failure and routine patients, Thawing frozen embryos in advance (18h) to extend the duration of embryonic development or thawing embryos on the day of transfer in the frozen embryo transfer cycle, to analyze which way can improve clinical pregnancy outcomes, is there a significant difference between the two ways or two types of patients?

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged <=35 years old;

  • Regular menstrual cycle;

  • Baseline follicle stimulating hormone (FSH) <12 IU/L;

  • Infertility, pure fallopian tube or/and male factor;

  • At least 2 high-quality day 3 embryos or 1 high-quality day 5 blastocyst are used forET.

Exclusion

Exclusion Criteria:

  • Patients with repeated transplant failure:

  • Abnormal uterus, such as adenomyosis, endometriosis, endometrial polyps or Ashermansyndrome;

  • Abnormal ovaries, such as low ovarian response and polycystic ovary syndrome (PCOS);

  • The endometrial thickness of FET day is <7 mm.

Study Design

Total Participants: 500
Study Start date:
January 01, 2020
Estimated Completion Date:
June 30, 2021

Study Description

Although in clinical practice, thawed embryos with appropriate development time will be selected strictly according to the number of days after ovulation, there are still two problems in actual clinical treatment: one is the embryonic factor, although the rate of embryonic development is generally the same, However, the phenomenon of delayed embryo division and development often occurs. The second is the endometrial factor. There are reports that a small number of people will move the transplant window forward, or the transplant window is narrow. This potentially creates the risk of embryo-endometrial mismatch. Based on this, the research team focused on patients with frozen embryo transfer cycles and put forward the strategy of "thawing embryos in advance and prolonging the development period of embryos properly" in an effort to achieve better repair of damage caused by embryo freezing and fine-tuning of embryo-endometrial interaction time. Therefore, it is necessary to compare thawing embryos in advance and thawing on the day of transfer on pregnancy outcomes in patients with repeated transplant failure and routine patients respectively.

The purpose of this study is to analyze which way can improve clinical pregnancy and birth outcomes, is there a significant difference between the two ways or two types of patients?

Connect with a study center

  • Jinan Central Hospital Affiliated to Shandong University

    Jinan, Shandong 250013
    China

    Site Not Available

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