Evaluation of the Effect of Pulmonary Rehabilitation on Patients With High Flow Oxygen Therapy

Last updated: February 6, 2026
Sponsor: Chinese PLA General Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Disease

Treatment

Pulmonary rehabilitation therapy

Clinical Study ID

NCT04441151
pulmonary rehabilitation
  • Ages 18-100
  • All Genders

Study Summary

Evaluation of the effect of pulmonary rehabilitation on patients with high flow oxygen therapy

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • The age is ≥ 18 years old;

  • the hemodynamics is stable;

  • 50 < heart rate < 120 beats / min ;

  • 90 < systolic blood pressure < 200mmHg ;

  • 55 < mean arterial pressure < 120mmHg;

  • do not increase the dose of pressor drugs for at least 2 hours;

  • intracranial pressure is stable and there are no seizures within 24 hours;

  • the respiratory state is stable;

  • the patient's finger pulse oxygen saturation ≥ 88%;

  • 10 < respiratory frequency < 35 beats / min.

Exclusion

Exclusion Criteria:

  • Pregnancy;

  • acute cardio-cerebrovascular events;

  • spinal or limb fractures;

  • active bleeding.

Study Design

Total Participants: 70
Treatment Group(s): 1
Primary Treatment: Pulmonary rehabilitation therapy
Phase:
Study Start date:
March 20, 2025
Estimated Completion Date:
February 01, 2026

Study Description

Objective: the purpose of this study was to evaluate the effect of lung rehabilitation on patients treated with high flow humidification apparatus in ICU. Methods: 70 patients in ICU who were treated with high flow humidification apparatus from June 2019 to June 2020 were randomly divided into two groups. The experimental group was treated with pulmonary rehabilitation and the control group was treated with routine medical treatment only. All patients were evaluated and measured by bedside diaphragm ultrasound. The vital signs of all patients were monitored every day. MRCsum assessment of peripheral muscle strength, 30s sitting test, modified Barthel index, Borg dyspnea score, arterial blood gas analysis and bedside diaphragm ultrasound monitoring were performed at admission and discharge. Finally, statistics were made on the use of non-invasive ventilator, endotracheal intubation, new complications (pressure sore, aspiration, thrombus, etc.) and the time of patients getting out of bed for the first time.The end point of the experiment was 28 days.

Connect with a study center

  • Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital

    Beijing, Beijing 100853
    China

    Site Not Available

  • Chinese PLAGH Hospital

    Beijing 1816670, Beijing Municipality 2038349
    China

    Active - Recruiting

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