Efficacy and Safety of Lenalidomide With or Without Rituximab and Other Drugs in B-cell Non-Hodgkin's Lymphomas

Last updated: July 6, 2020
Sponsor: Ruijin Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lymphoma, B-cell

Lymphoma

Treatment

N/A

Clinical Study ID

NCT04435743
LEN-NHL
  • Ages > 18
  • All Genders

Study Summary

Describe the treatment of B-cell non-Hodgkin lymphoma patients who receive lenalidomide single drug or lenalidomide combined with rituximab (with or without other drugs), and evaluate the efficacy and safety of lenalidomide single drug or lenalidomide combined with rituximab (with or without other drugs) in the real-world setting.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosed as B-cell non-Hodgkin's lymphoma

  • Voluntary participation in this study and the signing of an informed consent form

  • The researchers assessed that the patient will benefit from the treatment oflenalidomide single drug or lenalidomide combined with rituximab (with or withoutother drugs)

Exclusion

Exclusion Criteria:

  • Contradictions to any drug in the treatment regimen

  • Pregnant or lactating women

  • Patients who were not considered suitable for the study by the researchers

Study Design

Total Participants: 1000
Study Start date:
November 01, 2019
Estimated Completion Date:
December 31, 2022

Study Description

This is a multi-center prospective, observational real-world study, targeting patients with B-cell non-Hodgkin's lymphomas. This study is designed to evaluate the efficacy and safety of lenalidomide single drug or lenalidomide combined with rituximab (with or without other drugs) in the real-world setting.

This study will mainly focus on the following three cohorts:

Cohort 1: patients diagnosed with CD20-positive diffuse large B-cell lymphoma; Cohort 2: patients diagnosed with CD20-positive follicle lymphoma; Cohort 3: patients on maintenance treatment who have achieved complete remission or partial remission after induction therapy.

Connect with a study center

  • Shanghai Ruijin Hospital

    Shanghai,
    China

    Active - Recruiting

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