Intermittent Fasting in Nonalcoholic Fatty Liver Disease

Last updated: April 19, 2020
Sponsor: Shaoguan University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Obesity

Diabetes Prevention

Diabetes And Hypertension

Treatment

N/A

Clinical Study ID

NCT04355910
SGU-05
  • Ages 18-60
  • All Genders

Study Summary

Although preliminary evidence suggests that intermittent fasting mimic-diet (IFD) exerts stronger effects on body weight and metabolic parameters, which may link obesity, non-alcoholic fatty liver disease (NAFLD) and major chronic diseases, compared with continuous calorie restriction (CCR), there is a lack of well-powered intervention studies. This randomized controlled trial will test whether IFD, operationalized as the "5:2 diet," has stronger effects on anthropometric and body composition characteristics, and circulating metabolic biomarkers than CCR and a control regimen in adults with NAFLD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • The diagnosed criteria of fatty liver by ultrasound were presence of two of the threefollowing criteria: increased hepatic echogenicity compared with cortical of the rightkidney, blurring of liver vasculature, and deep attenuation of the ultrasonographicsignal.

Exclusion

Exclusion Criteria:

  • Excessive alcohol consumption (ethanol > 140 g/wk for men and > 70 g/wk for women),cirrhosis, viral hepatitis, cardiovascular disease, cancer, any consumption ofnonsteroidal anti-inflammatory drugs, corticosteroids or prescriptive medicine thataffect liver function, lipid and glucose metabolism.

Study Design

Total Participants: 120
Study Start date:
January 01, 2018
Estimated Completion Date:
August 31, 2020

Connect with a study center

  • Guangdong Medical University

    Dongguan, Guangdong 523808
    China

    Active - Recruiting

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