Measures of Mitochondria Dysfunction in PD

Last updated: November 3, 2020
Sponsor: University of Washington
Overall Status: Active - Recruiting

Phase

N/A

Condition

Mitochondrial Diseases

Treatment

N/A

Clinical Study ID

NCT04300608
STUDY00007024
  • Ages 65-85
  • All Genders

Study Summary

This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 65-85 years.
  • Ability to attend a 3-hour study visit in Seattle, WA.
  • Ability to read and speak English.
  • Hoehn & Yahr Stage 2-3. (bilateral disease, not severely disabled.)

Exclusion

Exclusion Criteria:

  • Any contra-indication to magnetic resonance imaging
  • A history of epilepsy, stroke, brain surgery, or structural brain disease.
  • The presence of other serious illnesses
  • Current or recent enrollment in a clinical trial involving an investigational productor device.
  • Supplementation with NAD, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and other nutraceuticals designed to target NAD for 30 days prior to baselinestudy visit.
  • Current drug or alcohol use or dependence.
  • Inability/unwillingness to provide informed consent. (e.g. diagnosis of dementia,confusion about study goals or participation.)
  • Acute infection (e.g. upper respiratory, dermal) in the previous 30 days.
  • Right limb tremor or dyskinesia that cannot be comfortably controlled for 90 minutes.

Study Design

Total Participants: 30
Study Start date:
February 24, 2020
Estimated Completion Date:
November 30, 2021

Study Description

The goal of this study is to identify the unique signature of bioenergetic markers and mitochondrial (dys)function in muscle of individuals with PD, who are 65-85 of age, read and speak English, have a Hoehn & Yahr score between 2 and 3 (bilateral disease, not severely disabled) and have a clinical diagnosis of PD. Bioenergetic markers and muscle functional properties will be compared to a control dataset collected over the last few years from healthy elderly subjects in the same age range to provide a foundation for future intervention studies.

Connect with a study center

  • University of Washington

    Seattle, Washington 98109
    United States

    Active - Recruiting

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