Investigation of Oxidative Markers and Antioxidant Defense in Female Patients With Osteoarthritis

Last updated: December 20, 2019
Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy
Overall Status: Active - Recruiting

Phase

N/A

Condition

Osteoarthritis

Treatment

N/A

Clinical Study ID

NCT04206462
UniversitateaIH
  • Female

Study Summary

Osteoarthritis has a multifactorial etiology: aging, genetic, sex, weight, alimentation, injuries, infections etc. The objective of the study is to investigate the eating behaviour of the patients included in the study by using a semiquantitative questionnaire (frequency and quantity) by estimating the foods that are known to be protective for osteoarthritis (vegetables, fruits, cereals) as the ones that are considered risk factors (meat origin, refined fats). Also, the oxidative-antioxidative balance will be evaluated by determining markers: oxidated glutathione/reducted glutathione, catalase enzyme, superoxide dismutase, glutathion peroxidase and malonyldialdehyde.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • osteoarthritis

  • signed informed consent

Exclusion

Exclusion Criteria:

  • drugs or foods with antioxidant effects

  • lack of judgement

  • refuse to participate

Study Design

Total Participants: 300
Study Start date:
July 17, 2019
Estimated Completion Date:
June 30, 2020

Study Description

A total of 300 patients with osteoarthritis will be included in the study. The objective of the study is to investigate the eating behaviour of the patients included in the study by using a semiquantitative questionnaire (frequency and quantity) by estimating the foods that are known to be protective for osteoarthritis (vegetables, fruits, cereals) as the ones that are considered risk factors (meat origin, refined fats). Also, the weight and height of each patient will be assessed and the patients will be included in 4 classes based on the body mass index: underweight, normal weight, overweight and obese. The type of physical activity will also be noted and the oxidative-antioxidative balance will be evaluated by determining serum markers: oxidated glutathione/reducted glutathione, catalase enzyme, superoxide dismutase, glutathion peroxidase and malonyldialdehyde. Correlation between eating behaviour, body mass index and oxidative stress markers will be made.

Connect with a study center

  • Clinical Rehabilitation Hospital

    Cluj Napoca,
    Romania

    Active - Recruiting

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