Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition

Last updated: November 17, 2020
Sponsor: University Hospital, Angers
Overall Status: Active - Recruiting

Phase

N/A

Condition

Brain Cancer

Brain Tumor

Gliomas

Treatment

N/A

Clinical Study ID

NCT04174820
49RC18_0010
  • Ages 6-17
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is thought to be related to axonal lesions. The long-term consequences on the cognitive and psychosocial sphere of PFS have been widely documented. On the other hand, the literature concerning the consequences of this syndrome on language is much restricted. Beyond the language, the role of cerebellum would be central in cognition, some authors even comparing it to a great "conductor" who would underlie the learning of most motor and cognitive automatisms.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient with a low grade glioma of the posterior fossa or a medulloblastoma
  • Healthy volunteers without any tumor in the posterior fossa (control case)
  • At one year of the last treatment for the retrospective groups, or patient who have anindication to a surgery of a tumor of the posterior fossa
  • Eligibility to a functional MRI
  • Informed consent dated and signed by the holder of the parental authority (if minor)or by the patient (if major) to take part in the study
  • Affiliated to a Social Security scheme

Exclusion

Exclusion Criteria:

  • Antecedent of neurologic, metabolic or genetic disease
  • Brainstem glioma
  • Have a contraindication to a MRI

Study Design

Total Participants: 145
Study Start date:
November 12, 2020
Estimated Completion Date:
November 01, 2022

Study Description

The physiopathology and the anatomo-functional correlates of motor, cognitive, and language functions after surgery of PF tumors are still rare and little known. The objective of this study is to analyze them via morphometric MRI analysis and functional and structural connectivity in children away from PF surgery, coupled with clinical data analysis.

Connect with a study center

  • CHU Angers

    Angers,
    France

    Active - Recruiting

  • Hôpital Necker

    Paris, 75015
    France

    Site Not Available

  • Institut Curie

    Paris, 75231
    France

    Site Not Available

  • Hôpitaux Saint-Maurice

    Saint-Maurice,
    France

    Site Not Available

  • Gustave Roussy

    Villejuif, 94805
    France

    Site Not Available

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