Sexual Dysfunction in Patients With Relapsing Remitting Multiple Sclerosis and Associated Comorbidities

Last updated: November 6, 2019
Sponsor: Mansoura University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sexual Dysfunction

Erectile Dysfunction

Infertility

Treatment

N/A

Clinical Study ID

NCT04157283
Mansoura University Hospital 3
  • Ages 20-45
  • All Genders

Study Summary

This work aims to:

  1. Investigate and correlate Sexual Dysfunction in relapsing-remitting Multiple Sclerosis patients with specific focus on

    1. Specific neurologic deficit.

    2. Depressive symptoms.

    3. Comorbid factors.

    4. Fatigue symptoms.

  2. To investigate the impact of Sexual dysfunction on Sexual Quality of Life (SQoL).

  3. To search for possible gender difference.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 120 MS adolescent patients meeting the McDonald's criteria; 60 male cases and 60female cases recruited from Mansoura University Hospitals

Exclusion

Exclusion Criteria: The exclusion criteria:

  • Active relapse or relapse during 30 day prior to survey due to significant changes inall life activities during this period including sexuality.

  • EDSS score equal or higher than 6.5.

  • Current pregnancy in female patients.

  • Form of the disease other than RRMS.

  • Patients with any sort of cognitive impairment preventing them from understandingQuestionnaire.

  • Poorly controlled concomitant diseases were excluded.

  • Patients with past history of any sexual problems prior to the first MS attack.

  • UN married Patients.

Study Design

Total Participants: 120
Study Start date:
November 05, 2019
Estimated Completion Date:
June 01, 2020

Study Description

The present study is a cross sectional study on 120 MS adolescent patients meeting the McDonald's criteria; 60 male cases and 60 female cases recruited from Mansoura University Hospitals, Egypt.

All patients were subjected to the following:

  1. Clinical Evaluation:

    1. Thorough neurological examination.

    2. Cognitive functions by Minimental State Examination (MMSE).

    e. Expanded Disability Severity Scale (EDSS).

  2. Neurophysiological Evaluation:

    a. Visual Evoked Potential (VEP).

  3. Imaging Evaluation:

    a. Conventional MRI.

  4. Cerebrospinal Fluid (CSF):

  5. Sexual dysfunction measure: through the international index of erectile function (IIEF), female sexual function questionnaire (SFQ) and the sexual Quality of life male and female version (SQoL) (American Psychiatric Association, 1994).

  6. Depressive symptoms assessment through The BDI (The Beck Depression Inventory) which is the most common instrument measuring the severity of depression.

  7. Fatigue symptoms were evaluated through fatigue subscale of Multiple Sclerosis Quality of Life-54(MSQOL-54).

Connect with a study center

  • Mansoura University Hospital

    Mansoura, Dakahlia 35516
    Egypt

    Active - Recruiting

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