Improving Outcomes in Cardiac Arrest With Inhaled Nitric Oxide

Last updated: October 18, 2019
Sponsor: Stony Brook University
Overall Status: Active - Recruiting

Phase

1

Condition

Circulation Disorders

Heart Attack (Myocardial Infarction)

Heart Failure

Treatment

N/A

Clinical Study ID

NCT04134078
648019
  • Ages > 18
  • All Genders

Study Summary

Sudden cardiac arrest (CA) is a leading cause of death worldwide. CA claims the lives of an estimated 300,000 Americans each year. Despite advances in cardiopulmonary resuscitation (CPR) methods, only approximately 10% of adults with CA survive to hospital discharge, and up to 60% of survivors have moderate to severe cognitive deficits 3 months after resuscitation. Most of the immediate and post-CA mortality and morbidity are caused by global ischemic brain injury. The goal of this grant application is to test the hypothesis that resuscitation from cardiac arrest can be improved by improving cerebral oxygenation through inhalation of nitric oxide. This strategy will also improve the chances of return of spontaneous circulation (ROSC), improve short-term survival and neurologic outcome.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age 18 years and above

  2. In-hospital cardiac arrest as defined by cessation of heartbeat

  3. Presence of Endotracheal Tube

Exclusion

Exclusion Criteria:

  1. Age below 18 years

  2. Absence of Endotracheal Tube

  3. Patients with out-of-hospital cardiac arrest

  4. Patients involved in trauma and/or patients in the SICU or CTICU

  5. Preexisting intra-cerebral lesions such as any head injury (old or new), brainhematoma, cerebral hemorrhage or known frontal lobe disorders such as tumors

  6. Any patient with a terminal condition that cannot be treated (specifically anyterminal malignancy, end stage lung fibrosis, chronic heart failure with an ejectionfraction <20%)

  7. Patients with do not resuscitate and/or do not intubate (DNR/DNI) status

  8. Therapeutic window has passed

Study Design

Total Participants: 100
Study Start date:
August 01, 2016
Estimated Completion Date:
July 31, 2022

Connect with a study center

  • Stony Brook University

    S. Setauket, New York 11720
    United States

    Active - Recruiting

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