Home Airway Clearance in CF Patients

Inclusion Criteria:

• Patient diagnosed with Cystic fibrosis

• Stabilization of the disease, defined by an at least 4 weeks period since the end ofan exacerbation, stabilization will be let to investigator's judgment.

• Age >12

• Requiring at least 1 bronchial clearing session each week (regardless of thetechnique)

• Patient (or patient's legal representative if applicable), capable to read andunderstand the procedure, and capable to express consent for the study protocol.

Exclusion Criteria:

• Severe pneumothorax or hemoptysis (more than 30ml per 24 hours) within 6 weeksbefore the inclusion day.

• Patient placed on a transplant waiting list

• Any contraindication to an instrumental bronchial clearance technique

• Patients already own and use SIMEOX at home

• Unavailable patient or patient wishing to move to a different region within threemonths after inclusion.

• Patient currently participating or having participated to another interventionalclinical research within a month prior inclusion date, that may impact the study,this impact is left to the investigator's judgment.

• Persons referred by the French Public Health Code to Articles L1121-5 to L1121-8 (includes all protected persons: pregnant women (confirmed by measurement of theserum human chorionic gonadotropin level for any woman wishing to enter the protocoland under childbearing age < 60), parturient woman, breastfeeding mother, everyonedeprived of his liberty by judicial or administrative decision, everyone subject toa legal protection measure.

• Initiation of treatment with a CFTR modulator within the last 3 months