Alternative Prophylaxis in Female Recurrent Urinary Tract Infections

Inclusion Criteria:

• Documented history of rUTI, defined as ≥ 3 episodes of (un)complicated UTIdocumented by urine culture with the isolation of ≥103 cfu/ml of an identifiedpathogen in the last year with clinical symptoms OR 2 episodes in the last 6 month

Exclusion Criteria:

• No informed consent

• Concomitant UTI (< 7 days prior to randomisation)

• Ongoing antimicrobial prophylaxis (e.g. for rUTI or for any other reason likeendocarditis, transplanted patients under immunosuppression)

• Ongoing prophylactic strategy (e.g. immunoactive prophylaxis)

• Documented underlying urogenital abnormality (e.g. significant post voiding residualvolume (>50 ml), urethral stricture, urethral diverticula, urinary stone, reflux,urinary neoplasia), urological device (e.g. catheter, ureteral stent) or symptomaticpelvic floor disorder (e.g. genital prolapse stage ≥ II)

• Concomitant disease (i.e. renal insufficiency, diabetes mellitus, corticosteroiduse)

• Urogenital urological or gynecological surgery < 6 weeks

• Known allergy to the study medication

• Use of spermicides or intrauterine device

• Pregnancy