The Role of Congenital Mucosal Immune System in the Airways of Patients With Chronic Obstructive Pulmonary Disease

Last updated: August 16, 2019
Sponsor: Medical Universtity of Lodz
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT04061122
RNN/206/16IKE
  • All Genders

Study Summary

The purpose of the study is to explore the role of congenital mucosal immune system in the airways of patients with COPD including the impact of ILCs (Innate lymphoid cells) on metabolism of epithelial cells.During the research the following methods will be applied: measurement of Volatile Organic Compounds (VOCS), airway epithelial cytology and culture.

Eligibility Criteria

Inclusion

Exclusion Criteria:

Exclusion

  • Neoplasm

  • Diabetes

  • Astma

  • acute airway infection in last 2 weeks

Study Design

Total Participants: 40
Study Start date:
July 04, 2018
Estimated Completion Date:
June 30, 2020

Study Description

ILCs profiles, epithelium metabolism measured by VOCS and microbiome profiling (specific 16S rRNA-16S ribosomal RNA gene-targeted qPCR) will by determined in the airways of patients with COPD after the exacerbation. Microbiome profiling will be based on next generation sequencing (NGS) of the 16S rRNA encoding region.

Connect with a study center

  • Department of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland

    Lodz, 90-153
    Poland

    Active - Recruiting

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