Botulinum Toxins Intralesional Injection for Scar Pain

Phase

Condition

Scar Tissue

Treatment

N/A

Clinical Study ID

NCT03982862

KMUHIRB-F(II)-20180062

Ages 18-60
All Genders

Study Summary

Botulinum toxins has been approved by the FDA to treat chronic migraine. Botox had been shown to inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerve to treat neuropathic pain. In the clinical practice, botox indeed effect in scar pain. However, investigators need well controlled study to prove this finding and assess the improvement of scar appearance.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Patients have visible hypertrophic scars or keloids over three months after trauma orsurgery.
Patients have symptoms of pain, itching or erythema.

Exclusion

Exclusion Criteria:

Patients had either Botulinum toxin type A or Triamcinolone intralesional before inthe same scar
The scar size is larger than 10 cm2
Immunocompromised status
Systemic infection status
Allergic to Botulinum toxin type A or steroids

Study Design

July 30, 2018

June 30, 2019

Study Description

After surgery or trauma, scar tissues would form during the healing process. However, hypertrophic scars and keloids might happen to some patients, both of which are often pruritic and erythematous. Besides, the markedly elevated tumor-like appearance usually brings much concern to patients. Moreover, significant pain or discomfort could happen to keloids. Various treatment strategies were mentioned but without a solid solution to all of the scars. Investigators hope to evaluate the differences of scar volume, appearance and symptoms (itching and pain) in participants receiving simultaneous intralesional injection of Botulinum toxin type A and/or steroids. Besides, side effects would also be recorded. Investigators hope to establish a more effective intralesional injection therapy for participatns suffering from hypertrophic scars and keloids.

Connect with a study center

Kaohsiung Medical University Hospital
Kaohsiung,
Taiwan
Active - Recruiting

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