Peritoneal Membrane Dysfunction in Peritoneal Dialysis Using Metabolomics

Last updated: May 24, 2019
Sponsor: Baxter (Hellas) Ltd
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT03964701
98550
  • Ages < 20
  • All Genders

Study Summary

Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal sclerosis

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Pediatric and adolescent patients on peritoneal dialysis

  • Aged:1month -20 years

Exclusion

Exclusion Criteria:

-Abdominal surgery

Study Design

Total Participants: 18
Study Start date:
April 22, 2019
Estimated Completion Date:
April 22, 2020

Study Description

Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal sclerosis. Identification of peritoneal membrane functional status changes over time, at the same patient (cohort study), by metabolomics, aiming in personalized medicine best practice.

Identification of peritoneal membrane functional status changes over time in immature infants' peritoneal membrane.

Identification of early and accurate markers of peritoneal membrane dysfunction when membrane status is possibly reversible that could predict peritoneal patients at risk for future loss of ultrafiltration and dialysis adequacy of small molecules examined today be PET, KT/V and Cr/Cl (when membrane status is not reversible).

Improve PD survival in infants and children.

Connect with a study center

  • 1st ACADEMIC PEDIATRIC DEPARTMENT

    Thessaloniki, 546 36
    Greece

    Active - Recruiting

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