Pulmonary Hemodynamics During Exercise - Research Network

Last updated: January 2, 2024
Sponsor: Medical University of Graz
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

assessment of pulmonary hemodynamics during exercise by right heart catheterization

Clinical Study ID

NCT03954574
30-437 ex 17/18
  • Ages > 18
  • All Genders

Study Summary

The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients (females and males; age: above 18yrs) with intermediate or highechocardiographic probability of PH and/or unexplained dyspnea, and/or associatedconditions for PAH as clinical indication for RHC at rest and exercise
  • Written informed consent of participating subjects after being fully briefed (forprospective analysis)

Exclusion

Exclusion Criteria:

  • Patients with incomplete hemodynamic data at rest or exercise
  • Patients without sufficient follow-up data (information on survival / lungtransplantation)
  • advanced tumour disease or other diseases with a short life expectancy, exceptpulmonary vascular diseases
  • advanced heart failure with pulmonary arterial wedge pressure (PAWP) > 18 mmHg at rest
  • uncontrolled systemic arterial hypertension (RR values > 160/100 mmHg at rest)
  • FEV1<50% predicted
  • TLC<60% predicted

Study Design

Total Participants: 1500
Treatment Group(s): 1
Primary Treatment: assessment of pulmonary hemodynamics during exercise by right heart catheterization
Phase:
Study Start date:
December 01, 2018
Estimated Completion Date:
December 31, 2029

Connect with a study center

  • Royal Prince Alfred Hospital, Respiratory Medicine

    Camperdown,
    Australia

    Active - Recruiting

  • Medical University of Graz

    Graz,
    Austria

    Active - Recruiting

  • Free University of Brussels, Faculty of Medicine, Physiology

    Brussels,
    Belgium

    Active - Recruiting

  • University of São Paulo Medical School

    São Paulo,
    Brazil

    Active - Recruiting

  • Department of Cardiology, Aarhus University Hospital, Denmark

    Aarhus,
    Denmark

    Active - Recruiting

  • Université de Lorraine

    Nancy,
    France

    Active - Recruiting

  • Centre Chirurgical Marie Lannelongue, Thoracic and Vascular Surgery

    Paris,
    France

    Active - Recruiting

  • Centre de Référence de l'Hypertension Pulmonaire, Université ParisSud - Université Paris-Saclay, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris

    Paris,
    France

    Active - Recruiting

  • Sorbonne Universités, Neurophysiologie respiratoire expérimentale et clinique

    Paris,
    France

    Active - Recruiting

  • University of Cologne, Klinik III fuer Innere Medizin

    Cologne,
    Germany

    Active - Recruiting

  • Justus-Liebig-University Giessen, Department of Internal Medicine

    Gießen,
    Germany

    Active - Recruiting

  • University of Greifswald

    Greifswald,
    Germany

    Active - Recruiting

  • Thorax Clinic Heidelberg, Centre for Pulmonary Hypertension

    Heidelberg,
    Germany

    Active - Recruiting

  • Academic Teaching Hospital of the Julius Maximilian University of Würzburg

    Würzburg,
    Germany

    Active - Recruiting

  • University of Bologna

    Bologna,
    Italy

    Active - Recruiting

  • University of Rome La Sapienza, Cardiovascular and Respiratory Sciences

    Roma,
    Italy

    Active - Recruiting

  • VU Medisch Centrum, Pulmonology

    Amsterdam,
    Netherlands

    Active - Recruiting

  • Otwock Medical Center of Postgraduate Education, Department of Pulmonary Circulation and Thromboembolic Diseases

    Otwock,
    Poland

    Active - Recruiting

  • Barcelona Hospital Clínic, Pneumologia

    Barcelona,
    Spain

    Active - Recruiting

  • University Hospital of Zurich, Internal Medicine

    Zürich,
    Switzerland

    Active - Recruiting

  • Scottish Pulmonary Vascular Unit

    Glasgow,
    United Kingdom

    Active - Recruiting

  • Imperial College, NHS Healthcare NHS Trust, National Pulmonary Hypertension Service

    London,
    United Kingdom

    Active - Recruiting

  • Royal Brompton Hospital

    London,
    United Kingdom

    Active - Recruiting

  • Royal Hallamshire Hospital, Sheffield Pulmonary Vascular Disease Unit

    Sheffield,
    United Kingdom

    Active - Recruiting

  • University of Arizona, Banner University Medical Center

    Phoenix, Arizona 85724
    United States

    Active - Recruiting

  • University of California, Los Angeles, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, David Geffen School of Medicine

    Los Angeles, California 90095
    United States

    Active - Recruiting

  • Johns Hopkins Hospital, Advanced HF, MCS, Transplant Cardiology, Baltimore, Maryland, USA

    Baltimore, Maryland 21287
    United States

    Active - Recruiting

  • Harvard Medical School, Brigham and Women's Hospital

    Boston, Massachusetts 02138
    United States

    Active - Recruiting

  • Massachusetts General Hospital, Cardiology Division and Pulmonary Unit

    Boston, Massachusetts 02114
    United States

    Active - Recruiting

  • University of Minnesota Medical School, Division of Cardiology, Department of Medicine, Lillehei Heart Institute Minneapolis, Minnesota, USA

    Minneapolis, Minnesota 55455
    United States

    Active - Recruiting

  • Mayo Clinic, Division of Cardiovascular Diseases, Department of Medicine

    Rochester, Minnesota 85259
    United States

    Active - Recruiting

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Active - Recruiting

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