Acute Mycoprotein Effect on Glycaemic Control in South Asians

Inclusion Criteria:

• Diagnosed with Type 2 Diabetes Mellitus without insulin treatment.

• South Asian (Afghanistan, Bangladesh, Bhutan, Maldives, Nepal, India, Pakistan and SriLanka) or Caucasian Ancestry.

• Age 18-70

• 5.5% ≤ HbA1c ≤ 9.0%

• BMI ≤ 35.0

• If anti-diabetic regime or lipid lowering drugs are used, they have to be stable andcontrolled for at least 2 months; regimes are expected to remain stable throughout theduration of the study or not being on anti-diabetic medication.

• If on oral hypoglycaemic agent, participant should have the last dose at 8pm of theday before each study visit.

• Willingness to comply with the study protocol, including:

• Use of standard evening meal the day prior to the assessments

• Refrain from alcohol consumption (24 h prior the visit) and extraneous physicalexercise (72 h prior to and during the assessments).

• Not changing physical activity routine or dietary habits for the duration of the study (except from the standard evening meal).

Exclusion Criteria:

• Not diagnosed with Type 2 Diabetes Mellitus

• Mixed ancestors

• Taking any of the following medications:

• Insulin

• Diabetic medication (except from Metformin or oral hypoglycaemic which are allowed).

• Orlistat

• Any gastrointestinal disease that interferes with bowel function and nutritionalintake (i.e. Diabetes related constipation or diarrhoea secondary to neuropathy orchronic inflammatory bowel disease, gastrectomy, etc.)

• Significant heart (New York Heart Association class IV), hepatic (transaminase levelsgreater than 3 times normal) or renal disease (requiring dialysis)

• Cancer

• Pancreatitis

• Major infections (requiring antibiotics) within 3 weeks before study entry

• Concomitant therapy with acarbose, meglitinides, insulin, systemic glucocorticoids orwithin 2 weeks prior to study entry

• History of alcohol and/or drug abuse

• Investigator's uncertainty about the willingness or ability of patient to comply withthe protocol requirements

• Participation in other nutrition trials within 3 months of study entry or drug trialswithin 5 months of study end

• Current smokers

• Allergic to test food or traces contained in the test food, breathing mould,penicillin, egg, soy

• Asthmatics.

• Any condition involving the imbalance of hormones

• Hypothyroidism.

• Weight change of ≥ 5% in the preceding 3 months

• Shift workers

• Vegetarian

• Medical implants that require batteries such as heart pace makers