Combination With Treg Levels and CMR to Assess the Severity and Prognosis of Reperfusion Injury After PPCI in STEMI Patients

Last updated: June 25, 2019
Sponsor: Beijing Friendship Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Disease

Blood Clots

Congestive Heart Failure

Treatment

N/A

Clinical Study ID

NCT03939338
BFH-Treg and CMR
  • All Genders

Study Summary

This study aims to determine whether combination with regulatory T cell (Treg) levels and cardiac magnetic resonance imaging (CMR) are predictive of the severity of reperfusion injury following myocardial infarction and the prognosis in STEMI patients receiving primary percutaneous coronary intervention (PPCI).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Confirmed STEMI diagnosis

  • Undergoing primary percutaneous coronary intervention (presenting <12 hours aftersymptom onset)

  • Patients were able to complete cardiac magnetic resonance imaging (CMR) and speckletracking imaging echocardiogram (STE) examinations

  • Patients agreed and provided informed consent

Exclusion

Exclusion Criteria:

  • Previous myocardial infarction or revascularization (PCI or CABG)

  • Congestive heart failure with LVEF<40%

  • Atrial fibrillation

  • Renal insufficiency (GFR < 30 ml/min/1.73m^2)

  • Acute infectious diseases within nearly 3 months

  • Rheumatic immune system diseases

  • Malignant tumors

  • Claustrophobia

  • Contraindicated to CMR

  • Patients do not agree to be included in the study

Study Design

Total Participants: 250
Study Start date:
July 01, 2019
Estimated Completion Date:
August 31, 2021

Connect with a study center

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing 100050
    China

    Active - Recruiting

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