S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease

Last updated: May 25, 2019
Sponsor: University Clinic Dr Dragisa Misovic-Dedinje
Overall Status: Active - Recruiting

Phase

N/A

Condition

Alcohol Use Disorder

Primary Biliary Cholangitis

Treatment

N/A

Clinical Study ID

NCT03938662
UCDragisaMisovic
  • Ages > 18
  • All Genders

Study Summary

The study will assess the effect of treatment with formulation containing S-Adenosyl methionine and choline, on patients with alcoholic liver disease.

Half of the patients included will receive named formulation once daily for 24 weeks while other half will receive placebo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • alcoholic liver disease

Exclusion

Exclusion Criteria:

  • hepatitis B

  • hepatitis C

  • autoimmune hepatitis

  • hemochromatosis

  • Wilson's disease

  • hepatocellular carcinoma

Study Design

Total Participants: 44
Study Start date:
May 09, 2019
Estimated Completion Date:
April 01, 2020

Study Description

Choline and S-Adenosyl methionine are nutrients both showing hepatoprotective effects.

Choline helps liver metabolise glucose and lipids and repair cell membrane. S-Adenosyl methionine is essential for the synthesis of glutathione, a main cellular antioxidant showing its protective effect against free radicals, among others in liver tissue. Furthermore S-Adenosyl methionine is involved in regulation of hepatocyte growth, differentiation, and death. It also enables endogenous production of small amount of choline. Although human organism has capacity for production of small amount of S-Adenosyl methionine, damaged liver can not produce it or produce it insufficient amounts.

Having this in mind it can be hypothesised that administration of choline and S-Adenosyl methionine can be beneficial in patients with alcoholic liver disease.

Connect with a study center

  • University Clinic Dr Dragisa Misovic-Dedinje

    Belgrade, 11000
    Serbia

    Active - Recruiting

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