Light, Metabolic Syndrome and Alzheimer's Disease - Aim 2

Last updated: September 11, 2025
Sponsor: Icahn School of Medicine at Mount Sinai
Overall Status: Completed

Phase

N/A

Condition

Alzheimer's Disease

Diabetes Prevention

Mental Disability

Treatment

Tailored Lighting Intervention

Clinical Study ID

NCT03933696
GCO 17-2685-0002
  • Ages > 55
  • All Genders

Study Summary

To test the long term effect of a light treatment on cognition, sleep and metabolism in patients with Mild cognitive impairment (MCI) or mild Alzheimer's disease or related dementia (ADRD).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Mild cognitive impairment

  • Mild Alzheimer's Disease

  • Sleep Disturbance

  • Live at home

Exclusion

Exclusion Criteria:

  • Blindness

  • insulin-dependent diabetes patients

  • macular degeneration

  • severe sleep apnea

Study Design

Total Participants: 25
Treatment Group(s): 1
Primary Treatment: Tailored Lighting Intervention
Phase:
Study Start date:
January 02, 2019
Estimated Completion Date:
May 31, 2025

Study Description

Test if a tailored light intervention (TLI) that promotes entrainment can improve sleep disturbances, inflammation, insulin sensitivity (Si) and glucose disposal (Sg) and cognition in patients with MCI and mild ADRD and sleep disturbances. Using a single-arm, between-subjects, placebo-controlled study the investigators will investigate if long-term (6-month) exposure to TLI improves glucose homeostasis and insulin sensitivity in patients with MCI and mild AD who suffer from sleep disturbance and are living at home. Participants will be recruited from the Mount Sinai AD research center (ADRC) and randomized to receive the TLI (or comparison control treatment) at home. The investigators hypothesize that, compared to the comparison light, a TLI will increase entrainment, improve sleep, reduce depression, reduce inflammation, improve metabolic control, increase insulin sensitivity, and reduce susceptibility to T2DM and metabolic disease during and after the completion of the 6-month intervention.

Connect with a study center

  • Rutgers University

    New Brunswick, New Jersey 08854
    United States

    Site Not Available

  • Rutgers University

    New Brunswick 5101717, New Jersey 5101760 08854
    United States

    Site Not Available

  • Icahn School of Medicine at Mount Sinai

    New York, New York 10029
    United States

    Site Not Available

  • Icahn School of Medicine at Mount Sinai

    New York 5128581, New York 5128638 10029
    United States

    Site Not Available

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