Graft Patency of QFR-guided Versus Angio-guided Coronary Artery Bypass Grafting

Last updated: December 9, 2018
Sponsor: Beijing Anzhen Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Myocardial Ischemia

Chest Pain

Heart Attack (Myocardial Infarction)

Treatment

N/A

Clinical Study ID

NCT03770520
Z171100001017059
  • Ages 18-80
  • All Genders

Study Summary

Coronary artery bypass grafting(CABG) is the golden standard for severe coronary artery disease(CAD), the current surgery strategy is mainly based on coronary angiography(CAG), but many trials of PCI have shown that visually stenosis in CAG may not have functional significance. The aim of this study is to investigate if the Quantitative Flow Ratio (QFR) can be adopted in CABG and achieve a better graft patency.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients with evidence of angina pectoris

  • left main or three vessels disease, have the indication for CABG after discussion ofthe heart team

  • at least one main vessels stenosis on 40%-70%

Exclusion

Exclusion Criteria:

  • former cardiac surgery patients

  • need to perform other cardiac or major surgery( i.e. valve surgery, carotidendarterectomy

  • emergent CABG

  • acute myocardial infarction time less than 7 days

  • life expectancy less than 3 years

Study Design

Total Participants: 208
Study Start date:
February 01, 2017
Estimated Completion Date:
August 30, 2020

Study Description

CABG is the major treatment of three vessels or left main disease. CAG is the main basis on choosing the vessels to graft, however, some of the grafts occluded shortly after surgery due to competitive flow, these vessels may not be significantly stenosis in functional assessment such as Fractional Flow Reserve (FFR). Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. Comparing to FFR, there is no need for pressure wire or ATP when performing QFR. This study plan to investigate the clinical effect of QFR in CABG, all patients included will be allocated 1:1 into two groups: QFR-guided and Angio-guided, QFR-guided group will be performed a CABG based on the result of QFR, the other group will be based on heart team discussion of CAG, CTA will be adopted to evaluate the 1 year graft patency.

Connect with a study center

  • Beijing Anzhen Hospital

    Beijing, Beijing 100029
    China

    Active - Recruiting

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