Serum Biomarkers for Portal Hypertension in Cirrhosis (Pan-CHESS1802)

Phase

N/A

Condition

Vascular Diseases

Stress

Williams Syndrome

Treatment

N/A

Clinical Study ID

NCT03713606

Pan-CHESS1802

Ages 18-75
All Genders

Study Summary

This is a prospective, multi-center diagnostic trial conducted at 6 liver centers in China designed to study the correlation between serum biomarkers associated with endothelial dysfunction and immune inflammation and hepatic venous pressure gradient in cirrhosis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

age 18-75 years;
confirmed cirrhosis based on histologic examination of liver or combined physical,laboratory, and radiologic findings, including a nodular surface, a coarse texture,and an enlarged caudate lobe of the liver.

Exclusion

Exclusion Criteria:

prior drug therapy (e.g. β-blocker, vasopressin) within two weeks
prior surgeries (e.g. TIPS, partial splenic embolization/ devascularization,splenectomy, liver transplantation)
non-sinusoidal portal hypertension & HCC inability to adhere to study procedures
pregnancy or unknown pregnancy status
no informed consent

Study Design

September 30, 2018

June 01, 2022

Study Description

Hepatic venous pressure gradient (HVPG) is the gold standard for assessing portal pressure, of which the measurement is invasive and therefore not suitable for routine clinical practice. The detection of serum biomarkers is potential for noninvasive diagnosis of portal hypertension in cirrhosis. However, many are still in the exploratory phases of testing and are not yet ready to enter clinical practice. This study prospectively enrolled participants in 6 liver centers (Beijing YouAn Hospital, Shandong Provincial Hospital, Beijing Shijitan Hospital, Beijing Friendship Hospital, Xingtai People's Hospital, and 302 Hospital of PLA) in China designed to study the correlation between serum biomarkers associated with endothelial dysfunction and immune inflammation and HVPG in cirrhosis.

Connect with a study center

302 Hospital of PLA
Beijing,
China
Active - Recruiting
Beijing Friendship Hospital
Beijing,
China
Active - Recruiting
Beijing Shijitan Hospital
Beijing,
China
Active - Recruiting
Beijing YouAn Hospital
Beijing,
China
Active - Recruiting
Shandong Provincial Hospital
Jinan,
China
Active - Recruiting
Xingtai People's Hospital
Xingtai,
China
Active - Recruiting

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